Protein Info for GFF1664 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Chemotaxis response regulator protein-glutamate methylesterase CheB (EC 3.1.1.61)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 349 PF00072: Response_reg" amino acids 6 to 108 (103 residues), 79.2 bits, see alignment E=2.7e-26 PF01339: CheB_methylest" amino acids 159 to 336 (178 residues), 234.6 bits, see alignment E=6e-74

Best Hits

Swiss-Prot: 100% identical to CHEB_SALPA: Protein-glutamate methylesterase/protein-glutamine glutaminase (cheB) from Salmonella paratyphi A (strain ATCC 9150 / SARB42)

KEGG orthology group: K03412, two-component system, chemotaxis family, response regulator CheB [EC: 3.1.1.61] (inferred from 98% identity to cko:CKO_01069)

MetaCyc: 95% identical to protein-glutamate methylesterase/protein glutamine deamidase (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Chemotaxis response regulator protein-glutamate methylesterase CheB (EC 3.1.1.61)" in subsystem Bacterial Chemotaxis (EC 3.1.1.61)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.1.61

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (349 amino acids)

>GFF1664 Chemotaxis response regulator protein-glutamate methylesterase CheB (EC 3.1.1.61) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MSKIRVLSVDDSALMRQIMTEIINSHSDMEMVATAPDPLVARDLIKKFNPDVLTLDVEMP
RMDGLDFLEKLMRLRPMPVVMVSSLTGKGSEVTLRALELGAIDFVTKPQLGIREGMLAYS
EMIAEKVRTAARARIAAHKPMAAPTTLKAGPLLSSEKLIAIGASTGGTEAIRHVLQPLPL
SSPAVIITQHMPPGFTRSFAERLNKLCQISVKEAEDGERVLPGHAYIAPGDKHMELARSG
ANYQIKIHDGPPVNRHRPSVDVLFHSVAKHAGRNAVGVILTGMGNDGAAGMLAMYQAGAW
TIAQNEASCVVFGMPREAINMGGVSEVVDLSQVSQQMLAKISAGQAIRI