Protein Info for GFF1662 in Variovorax sp. SCN45

Annotation: Transcriptional regulator, GntR family domain / Aspartate aminotransferase (EC 2.6.1.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 495 transmembrane" amino acids 335 to 357 (23 residues), see Phobius details PF00392: GntR" amino acids 23 to 82 (60 residues), 33.2 bits, see alignment E=3.4e-12 PF00155: Aminotran_1_2" amino acids 141 to 480 (340 residues), 85.1 bits, see alignment E=5.9e-28

Best Hits

KEGG orthology group: K00375, GntR family transcriptional regulator / MocR family aminotransferase (inferred from 65% identity to rsl:RPSI07_0369)

Predicted SEED Role

"Predicted transcriptional regulator of pyridoxine metabolism" in subsystem Pyridoxin (Vitamin B6) Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (495 amino acids)

>GFF1662 Transcriptional regulator, GntR family domain / Aspartate aminotransferase (EC 2.6.1.1) (Variovorax sp. SCN45)
MDYSALLAAHAREDPNGPATRQHRLYAGLRWAILGGQIAEGTRLPSTRALAEELGMARNS
VLYAYEHLGTEGFLRSSRHGTVVAQLDLERGRGAIALDAARACTPTLSRRALALQTEQDD
ANRSLPLWPGMPALDAFPLAAWRRCMERAWRHAGARQLGYAPVQGHLPLRQAIAQYLRVS
RGVRCTAEQVFISDGSQGGLELCARTLADVGDTAWIENPGYPGARAAFQAADLRLVPIGV
DDEGLAPSAEDWRATPPRLIYITPSHQYPLGAMMSLERRLALIRQAREAGAWLIEDDYDS
EFRSEGLPLSAVQGLDAHAPVVYVGTFSKTLFPALRLGFMVVPAAVAPALLGAISAAGMR
GRLAEQVALADFIESGQFTLHLRRMRQLYGRRREALQEALQRHLRGVVTVSGGAGGMHLS
VRLHTPVPDTAVSRAARAQGLGLRPLSLFCLPGVAKGDGNGFVLGYAGMPPEHADELVRR
MGRVIAQVSREAAGG