Protein Info for GFF1654 in Xanthobacter sp. DMC5

Annotation: Bifunctional chorismate mutase/prephenate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

KEGG orthology group: K04518, prephenate dehydratase [EC: 4.2.1.51] (inferred from 91% identity to xau:Xaut_2629)

Predicted SEED Role

"Prephenate dehydratase (EC 4.2.1.51)" in subsystem Chorismate Synthesis or Phenylalanine and Tyrosine Branches from Chorismate (EC 4.2.1.51)

MetaCyc Pathways

superpathway of aromatic amino acid biosynthesis (18/18 steps found)
superpathway of L-phenylalanine biosynthesis (10/10 steps found)
L-phenylalanine biosynthesis I (3/3 steps found)
L-phenylalanine biosynthesis III (cytosolic, plants) (2/2 steps found)
superpathway of chorismate metabolism (41/59 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.51

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (288 amino acids)

>GFF1654 Bifunctional chorismate mutase/prephenate dehydratase (Xanthobacter sp. DMC5)
MPMTRRITFQGEPGANSHIACREVFPDFEAVPCPTFEDAFAAVENGAAAYAMIPIENSVA
GRVADIHHLMPQSSLSIVGEYFLPLSHQLMAVKGASLSTLKTVQSHVMALGQCRKAIRTL
SLTPIIGADTAGSAREIAESNDLSRAAIASRLAADIYGLEILAENIEDEAHNTTRFIILT
RGADWAPAGRGPVITTFVFRVRNVPAALYKAMGGFATNGVNMTKLESYQLDGQFTATQFY
ADVEGHPDDRSVKLALEELAFFSREMRILGVYPAHPYRARFGDSDPSI