Protein Info for GFF1640 in Variovorax sp. SCN45

Annotation: Polyketide synthase modules and related proteins

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00109: ketoacyl-synt
  • amino acids 15 to 267 (253 residues), 244.5 bits, E=8.8e-76
• PF02801: Ketoacyl-synt_C
  • amino acids 275 to 395 (121 residues), 139 bits, 4.8e-44
• PF16197: KAsynt_C_assoc
  • amino acids 397 to 512 (116 residues), 75.4 bits, 3.1e-24
• PF22621: CurL-like_PKS_C
  • amino acids 461 to 521 (61 residues), 67.7 bits, see alignment (E = 4.7e-22)
• PF22336: RhiE-like_linker
  • amino acids 465 to 524 (60 residues), 49.6 bits, see alignment (E = 2.1e-16)
• PF00698: Acyl_transf_1
  • amino acids 546 to 864 (319 residues), 178.8 bits, E=1.3e-55
• PF21394: Beta-ketacyl_N
  • amino acids 939 to 1107 (169 residues), 31.8 bits, 6.9e-11
• PF08659: KR
  • amino acids 1161 to 1357 (197 residues), 154 bits, E=2.7e-48
• PF00106: adh_short
  • amino acids 1163 to 1329 (167 residues), 32.3 bits, 4.5e-11
• PF13561: adh_short_C2
  • amino acids 1214 to 1302 (89 residues), 32.5 bits, see alignment (E = 4.4e-11)
• PF00550: PP-binding
  • amino acids 1449 to 1511 (63 residues), 57.7 bits, see alignment (E = 7.3e-19)
• PF00668: Condensation
  • amino acids 1537 to 1986 (450 residues), 352.9 bits, E=1.7e-108
• PF02668: TauD
  • amino acids 2043 to 2332 (290 residues), 155.2 bits, E=2.1e-48

Predicted SEED Role

"Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 2.3.1.39)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• fatty acid biosynthesis initiation (type II) (3/3 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• fatty acid biosynthesis initiation (mitochondria) (2/4 steps found)
• fatty acid biosynthesis initiation (plant mitochondria) (1/4 steps found)
• mycobactin biosynthesis (4/11 steps found)
• pederin biosynthesis (2/14 steps found)
• bryostatin biosynthesis (2/19 steps found)
• mupirocin biosynthesis (1/26 steps found)
• corallopyronin A biosynthesis (2/30 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.39

Use Curated BLAST to search for 2.3.1.39

Protein Sequence (2360 amino acids)

>GFF1640 Polyketide synthase modules and related proteins (Variovorax sp. SCN45)
MQDQATLPTGLTGIEIAIVGMAGRFPGAPDVDTFWRNIRDGVESVTVFSDEQLRARGVPE
RTLADPDYVKAGVLFEGFDQFDAGFFGYSPREAEHLDPQQRIFLECAWEALEHAGWQARK
AAASVGVYAGDGPNLYLMRHLLPAFGIDAGTGIADMLGLMSGNSAGSLCTRVAYKLDLRG
PAVSVQTECSTSLVAVHMACQALLNHDCDMALAGGVWLNLLQEGGYRYQNGAILSPDGHC
RAFDAKAAGTVIGSGAGIVVLKRLEEALRDGDTIHAVIKGSAANNDGADKIGFTAPSVQG
QAGAIRAAQMVADVPASTIGYVEAHGTGTTLGDPIEMAALTQAFASGGATSQGRCAIGSV
KTNIGHLDAAAGVAGLIKAAMALRHRTLPPSLHFEQPNPQIDFATSPFYVNTEARPWPKG
DAPRRAGVSSFGIGGTNVHVVLEEAPEAPAAAAPQDQGGWQVLPLSAMSATAVKQAAQRL
GAHIEAHPGTALADIAHTLQTGRRAFAHRRAVVADASAAAAGMLACREGVMAAAAPAPEQ
PPEVAFLFPGGGTQHANMGLALYREDAPFRKDIDRCCELLRPELGLDLRELLFPAPHAQA
EADARLFDIAFAQPALFVVEYAMAHWWMRRGVRPAVMIGHSLGEYVAACLAGVFRLEDAL
RVTALRGRLLQSMPPGAMTAVPLSQAELAPFLTGGCDLGAANGEQLCVISGPLEAIEATE
AELRAHGHLPRRLHVSIASHSAMTQPLLAQLEQLIASVPRQAPKIPFISNVTGKLITAQQ
ATSPNYWAQHLRGTVQFTDGLRSLFEVPGRVVLEVGPGETLAGLARQHPMAVSAAAVHAS
QAHPQQRARNAQQIAQTLASLWLAGVDIDWAACHAGQARRRVPLPAYPFQRRRYWVDAPG
AGSAKSARKPSADAFYVPVWKRIEPLVPVVPRTAADAGCVLVLGDGRSLTGHLARHLRSL
GHAVAVAERGTAFARTGREGWTLRPGERDDHARLLREVEADFGAVAAIHHLWCLDEVPAS
QPQAELLERSFFSLLALVQALDTRTTAAAAGKLPITVVANQIEDVTGTEPLCPEKATLLG
AAKVIGQECPRVHCRVIDVMLPAAESDAEALLVAQLATESAALRTEPGEPLLAYRGPHRW
AKGYEPAPLPAAAQPRLRPQGVYLITGGLGGVGLAVAKHLARHWQARLVLLGRSAMPERA
CWAALAGDASQPEAQKARLRQLLELEALGAQVMALSADVSDAAQLQAALALANARFGALH
GIVHAAGDAGGGMLAQRTRAQVDTVFATKVRGTRVLLDAVRGQPLDFVQFCSSISSVAGG
LGMGDYAAANAYLDAVAIAHARAGSYPIFSVNWDAWRGLGMAQNMDVPDGIGMDGPEGAR
TFERIVNGPLRPQTVISTTDLAQRLGPLDSGMLDMFETDDAQPAASGGSHPRPALQTPFV
APEGELANALAALWTERLGIAPIGMDDNLFELGGDSLVAIQLLSRIRKAYAVELHPSEFF
KAPTIAGLIARMPANGAPAEARQAAAMEMAPVPRTGALPLSPMQRRLWLVDRLTDAGNVT
GRAAYNMSAGLALHGELNVDVLRAAIDAIVARHEVLRTVFAEDDEGEPAAVIRDSVRLNI
PLVEIDEADKPARERRYAMLFDELVRMPFALAEGPLIKATVVRLGEREHVLVLVVHHIVF
DGWSIAVFARELGEFYERALRGQPLALAPLPVQYVDYAAWYDRALASETFAPKAEFWRSY
LRNAPQVSTLQSDHQRPATASHAGNSVVLELPPDLSQALAALARECDTSLFTLLLSSFFL
FFHQASGADDIVIGTDVAGRGHPDLEQLLGFFVNVVPVRSRMSERQADFRQWLARTKQQT
LVAMDHQDVPFDQIVELSGAQRARDRNPLVQVLFVLQNTPEIRFAIEGAEVEVLPQQMNE
SKFDLAVFAREQAGALTVEWVYATDLYRRETVEKFTASWHALLERIVETPGQAVETIEAP
APKQSQERITMNTAKTTGAAGKMDKLGKLDKLGKLGKAAARPVVQTSFLRAGAEFPIVLQ
ATTDDLDTVAWAKSQADYIEMLVARHGGILFRNFGLKTPQDFEAFAEAIEPELYGSYGDL
PKKEGGKKTYRSTPYPERQMILYHNESSHLDRWPRKQWFFCELPSPVGGATPIVDCREML
RRLPADMVAEFERKELLYVRTFTPGLDVSWRDFYKTDRREDVEARLAAAGIAWRWLDEDT
LQTRTRCPAVIRHPLTGEKVFFNQIQLHHVACLEAQVREDLLAMGGIERMPRNVTYGDGS
PIADETMAVVGRVYEECAVRFDWQQGDIVMLDNMLAAHARDPYEGPRKIVVAMGAMFDRG
ALEGAAPAANEAKLADEQGA