Protein Info for GFF1624 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Protease II (EC 3.4.21.83)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 683 PF02897: Peptidase_S9_N" amino acids 3 to 403 (401 residues), 394.6 bits, see alignment E=5.1e-122 PF00326: Peptidase_S9" amino acids 463 to 674 (212 residues), 222.8 bits, see alignment E=3.7e-70

Best Hits

Swiss-Prot: 90% identical to PTRB_ECOLI: Protease 2 (ptrB) from Escherichia coli (strain K12)

KEGG orthology group: K01354, oligopeptidase B [EC: 3.4.21.83] (inferred from 92% identity to cko:CKO_01121)

MetaCyc: 90% identical to oligopeptidase B (Escherichia coli K-12 substr. MG1655)
Oligopeptidase B. [EC: 3.4.21.83]

Predicted SEED Role

"Protease II (EC 3.4.21.83)" (EC 3.4.21.83)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.83

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (683 amino acids)

>GFF1624 Protease II (EC 3.4.21.83) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MLPKANRIPYAMTVHGDTRIDNYYWLRDDTRSQPEVLDYLHQENEYGRKVMTSQQALQDR
ILKEIIDRIPPREVSAPYVKNGYRYRYIYEPGCEYAIYQRQSALSEEWDVWETLLDANQR
AAHSEFYTLGGLAITPDNTIMALAEDYLSRRQYGLRFRNLESGNWYPELLDNVAPEFVWA
NDSLTLYYVRKHKKTLLPYQVWRHTIGTPSSQDELVYEEKDDTFYVSLHKTTSQHYVVIH
LASATTSEVLLLDAELADAEPFSFLPRRKDHEYSLDHYQHKFYLRSNRNGKNFGLYRTRV
RNENAWEELIPPREHIMLEGFTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAY
VTWLAYNPEPETSRLRYGYSSMTTPDTLFELDMDTGERRVLKQTEVPGFDSGCYQSEHLW
ITARDGVEVPVSLVYHQKYFRKGQNPLLVYGYGSYGSSIDADFSSSRLSLLDRGFVYAIV
HVRGGGELGQQWYEDGKFLKKRNTFNDYLDACDALLKLGYGSPSLCYGMGGSAGGMLMGV
AINERPELFHGVIAQVPFVDVLTTMLDESIPLTTGEFEEWGNPQDIEYYDYMKSYSPYDN
VKAQDYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDQRLLLLCTDMDSGHGGKSGRFK
SYEGVALEFAFLIGLAQGTLHSA