Protein Info for GFF162 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Probable transcriptional activator for leuABCD operon

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 314 PF00126: HTH_1" amino acids 24 to 81 (58 residues), 64.9 bits, see alignment E=5.1e-22 PF03466: LysR_substrate" amino acids 125 to 312 (188 residues), 58.5 bits, see alignment E=6.2e-20

Best Hits

Swiss-Prot: 100% identical to LEUO_SALTY: Probable HTH-type transcriptional regulator LeuO (leuO) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K05798, LysR family transcriptional regulator, transcriptional activator for leuABCD operon (inferred from 99% identity to sty:STY0134)

Predicted SEED Role

"Probable transcriptional activator for leuABCD operon" in subsystem Leucine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (314 amino acids)

>GFF162 Probable transcriptional activator for leuABCD operon (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MPEVKTEKPHLLDMGKPQLRMVDLNLLTVFDAVMQEQNITRAAHTLGMSQPAVSNAVARL
KVMFNDELFVRYGRGIQPTARAFQLFGSVRQALQLVQNELPGSGFEPTSSERVFNLCVCS
PLDNILTSQIYNRVEKIAPNIHVVFKASLNQNTEHQLRYQETEFVISYEEFRRPEFTSVP
LFKDEMVLVASRKHPRISGPLLEGDVYNEQHAVVSLDRYASFSQPWYDTPDKQSSVAYQG
MALISVLNVVSQTHLVAIAPRWLAEEFAESLDLQILPLPLKLNSRTCYLSWHEAAGRDKG
HQWMEDLLVSVCKR