Protein Info for GFF1611 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Glycine cleavage system transcriptional activator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 342 PF00126: HTH_1" amino acids 17 to 73 (57 residues), 79.1 bits, see alignment E=2e-26 PF03466: LysR_substrate" amino acids 105 to 222 (118 residues), 54.8 bits, see alignment E=8.5e-19 amino acids 239 to 322 (84 residues), 41.2 bits, see alignment E=1.2e-14

Best Hits

Predicted SEED Role

"Glycine cleavage system transcriptional activator" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (342 amino acids)

>GFF1611 Glycine cleavage system transcriptional activator (Hydrogenophaga sp. GW460-11-11-14-LB1)
MQLTSSHPRTRPIAAGHLRAFEAVARHLNFRAAAEELSLTQSAVSRQIQSLEDEVGTALF
LRHTRAVELTSAGSQLLRASSMALERIDAAVRQIRQSAGRKGVAITTWASFASMWLIPRL
EAFQRDHPDIDIRIDATDAAVDLATSDVDIALRYAVPQAMPADAQRLFGEQLTPVASPWL
LKTHPIHSIDDLSRCALIEAGDAHRTRHLEWLTWQRWLDTFGHKPAATPGKRPGRNTPAK
LTPQRWMYFNYANQIVQAALTGQGVALARLPLVAESLASGALVEPLPHTRLDSPLVYWLM
VAPRSAQRPEVKAFCEWLLQQAAETREAIGDVPDPDTVDQMD