Protein Info for GFF1597 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 618 (617 residues), 776.8 bits, E=7.7e-238
• PF13522: GATase_6
  • amino acids 62 to 190 (129 residues), 70.6 bits, E=2e-23
• PF13537: GATase_7
  • amino acids 98 to 205 (108 residues), 60.4 bits, E=2.5e-20
• PF01380: SIS
  • amino acids 302 to 423 (122 residues), 81.7 bits, E=6.4e-27
  • amino acids 474 to 599 (126 residues), 78.5 bits, E=6.2e-26

Best Hits

Swiss-Prot: 77% identical to GLMS_BORPA: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 86% identity to pol:Bpro_0675)

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (5/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.16

Protein Sequence (618 amino acids)

>GFF1597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MCGIVAGVSGRDIVPVLVQGLQRLEYRGYDSCGVAVHSGGLQRARSTSRVAELAQQVQQE
AIASGTGIAHTRWATHGAPAVHNAHPHFSHGPGATAGAAGRVALVHNGIIENHDELRAAL
QAKGYVFESQTDTEVIAHLIDSLYEGDVFAALQSAVAQLHGAFALAVFHKDEPHRVVGAR
AGSPLVLGVGQGGAEHFLASDAMALAGVTDQIVYLEEGDLVDLQLGRYWVLDASGRALSA
EQRPVKTVQAHSGAAELGPYRHYMQKEIFEQPRAIGDTLEGLGGITPELFGDGAYSVFKE
IDNVLILACGTSYYSGCTAKYWLEDIAKIPTQVEVASEYRYRTSVPNPRTLVVTITQSGE
TADTLAALRHAQSLGMKHTLTVCNVATSAMVRECELAYITRAGVEIGVASTKAFTTQLAG
LFLLTLALAQSRGHLSEEAEAEHLKAMRHLPVALQAVLALEPQVISWAEDFARMDNALFL
GRGLHYPIALEGALKLKEISYIHAEAYPAGELKHGPLALVTAAMPVVTVAPNNALLEKLK
SNMQEVRARGGVLYVLADADTRIASSEGIHVIRMPEHYGALSPLLHVVPLQMLAYHTALA
KGTDVDKPRNLAKSVTVE