Protein Info for PS417_08085 in Pseudomonas simiae WCS417

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 504 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF00496: SBP_bac_5" amino acids 71 to 422 (352 residues), 323 bits, see alignment E=1.4e-100

Best Hits

KEGG orthology group: K02035, peptide/nickel transport system substrate-binding protein (inferred from 98% identity to pfs:PFLU1636)

Predicted SEED Role

"Dipeptide-binding ABC transporter, periplasmic substrate-binding component (TC 3.A.1.5.2); Putative hemin-binding lipoprotein" (TC 3.A.1.5.2)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7TZF2 at UniProt or InterPro

Protein Sequence (504 amino acids)

>PS417_08085 diguanylate cyclase (Pseudomonas simiae WCS417)
MQSRHLKLLAAATLTAWSLTAGLAQAAGVLTIGCREDSTTFDPIKSAQNRDTWVFANVYD
TLVRVDNLGTKMEPGLAESWDISKDGLTYTFKLRDAKFSDGSAITADDAAFSLLRIRDNK
ASLWADPFNLINTAKASDPKTLVVTLKTPAVAFLSQLASPTVSILSEKAMTKMGEDAYSE
NPVTSGAFTVDEWRKGDRVILKKNPNFWQAKNVSLDGVEWVSVTDDNTRMRMVQNNELDT
AIFVPFSRVEELKKDKNVVIHADPSTREDHLLINHEHGLLAKPEVRQALDMAIDKQSLVK
TATYGQGTVAYSYIPKGSLYHYANNLQRPYDPTAAKKLLEQAGAKDLKLNYVVNAGNEAD
EQIAVIIKDQLAKVGVTANLQKVDPTQSWQMLVDGEYDISVMYWTNDILDPDQKTTFVLG
HDTNQNYMTRYKNDKVKALVAQARIEADPVKREQMYVELQKLAKQDVNWIDLYYSPYINI
SRKNVSNFLQNPLGRFTLEEVVKN