Protein Info for GFF1574 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Nicotinamidase (EC 3.5.1.19)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.

Best Hits

KEGG orthology group: None (inferred from 43% identity to aav:Aave_0977)

Predicted SEED Role

"Nicotinamidase (EC 3.5.1.19)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation or Redox-dependent regulation of nucleus processes (EC 3.5.1.19)

MetaCyc Pathways

• NAD salvage pathway I (PNC VI cycle) (6/7 steps found)
• NAD salvage pathway V (PNC V cycle) (4/5 steps found)
• superpathway of NAD biosynthesis in eukaryotes (10/14 steps found)
• aldoxime degradation (2/3 steps found)
• NAD salvage (plants) (6/11 steps found)

KEGG Metabolic Maps

• Nicotinate and nicotinamide metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.19

Protein Sequence (271 amino acids)

>GFF1574 Nicotinamidase (EC 3.5.1.19) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MRTKLLIIDPQNDFCDIEGAALPVAGADEDLRRLARFIEAHTARIDDITVTLDSHASVAV
ERTTFWLDREGRTVAPFTFITAASVAAGEHRPRDAGLTGQVVAMLDQLAAAGKAGMVVWP
VHCVTATWGHNIQRAVADSLAVWEMAHQRAVTKVLKGEYPLTEHFGVFEADAPVASVPST
QFNRALAASVASGADVVAFAGQASSHCVAASYDQFMRFLAGSPAFAPQVVLLRDCMSPVP
GFETLADGLFERARAAGSLVLSVDEFAARIC