Protein Info for GFF155 in Sphingobium sp. HT1-2

Annotation: Ferrichrome-iron receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 734 signal peptide" amino acids 1 to 40 (40 residues), see Phobius details PF07715: Plug" amino acids 70 to 173 (104 residues), 67.7 bits, see alignment E=1.2e-22 TIGR01783: TonB-dependent siderophore receptor" amino acids 72 to 734 (663 residues), 280.6 bits, see alignment E=1.5e-87 PF00593: TonB_dep_Rec_b-barrel" amino acids 245 to 703 (459 residues), 200.8 bits, see alignment E=7.7e-63

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 43% identity to nar:Saro_2950)

Predicted SEED Role

"Ferrichrome-iron receptor" in subsystem Iron acquisition in Vibrio or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (734 amino acids)

>GFF155 Ferrichrome-iron receptor (Sphingobium sp. HT1-2)
MSIQFLPRACAAPVRSRRFHRIARALPLAAVLAWFPAQAQTGDAVHHVPEGEGAITVDGV
RQAYRGDFSVKEIPQAITEIDAETLQQNNILRLTDALDMNASVARQNTLGGLWDSFAIRG
FAGDENLPSGYLVNGFNAGRGFGGQRDVAGIERVEVLKGPAAALIGRGEPGGTINLVTKQ
AEIGRTFGGGSLQYGSYDRFRADADANLALTEGITARLIGYYEKGDTFRDYVSQKRWGFL
PSIGVALGDRTRLTYDFEWTRVEVPFDRGIVVLNNDFNTVPRSRFLGEPGDGDTVARATG
HQLRLDHQFNDDWSLLVGASHRDTLLTGFSSDAGQTASRQKLYVDGHSLSRQRRSRRYDA
EHSVVRAEVAGKFETGSLHHRVLIGGDFDHFRYDNYFTRYRPPALSSNPSDQAGYVIDID
NPVYGQYPLPATSVLTNRLDTQRSFGFYVQDQIELTERLQIRIGGRYDNLTLKVDNRVLA
EANRHNSRKYERFSPQAGIVYDLSDPITLYAAYGQGYRANVGADFFNNIFDPETSESIEA
GVKLTALGGALTGTLSVYQLTKKNVLASDNNNPGFSVAIGKARSRGIELDVNGHLPGDID
VLLSYAYTDAEAREAVNDPNFATQILPGDKLISIPDHNLNIQIAKHFEIGGRGAQLGAGM
QYVGERLGETGTDFTLPSHTLFRLFGSVDVIEGVELFGTISNLFDETWYASSYSSVWVQP
GTPRTATVGVRARF