Protein Info for GFF1518 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868
Annotation: Phosphoheptose isomerase (EC 5.3.1.-)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to DIAA_SALSV: DnaA initiator-associating protein DiaA (diaA) from Salmonella schwarzengrund (strain CVM19633)
KEGG orthology group: K12961, DnaA initiator-associating protein (inferred from 98% identity to eco:b3149)MetaCyc: 41% identical to D-sedoheptulose 7-phosphate isomerase (Aneurinibacillus thermoaerophilus)
RXN0-4301 [EC: 5.3.1.28]
Predicted SEED Role
"Phosphoheptose isomerase (EC 5.3.1.-)" in subsystem Capsular heptose biosynthesis or LOS core oligosaccharide biosynthesis (EC 5.3.1.-)
MetaCyc Pathways
- ADP-L-glycero-β-D-manno-heptose biosynthesis (5/5 steps found)
- GDP-D-glycero-α-D-manno-heptose biosynthesis (1/4 steps found)
KEGG Metabolic Maps
- Biosynthesis of ansamycins
- Galactose metabolism
- Inositol phosphate metabolism
- Pentose and glucuronate interconversions
Isozymes
Compare fitness of predicted isozymes for: 5.3.1.-, 5.3.1.28
Use Curated BLAST to search for 5.3.1.- or 5.3.1.28
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (196 amino acids)
>GFF1518 Phosphoheptose isomerase (EC 5.3.1.-) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868) VLERIKVCFTESIQTQIAAAEALPDAISRAAMTLVHSLLNGNKILCCGNGTSAANAQHFA ASMINRFETERPSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRG NSRDIVKAVEAAVTRDMTIVALTGYDGGELAGLLGPQDVEIRIPSHHSARIQEMHMLTVN CLCDLIDNTLFPHQDD