Protein Info for GFF1506 in Variovorax sp. SCN45

Annotation: ABC transporter, substrate-binding protein (cluster 5, nickel/peptides/opines)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 521 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF00496: SBP_bac_5" amino acids 64 to 434 (371 residues), 313.6 bits, see alignment E=9.8e-98

Best Hits

KEGG orthology group: K02035, peptide/nickel transport system substrate-binding protein (inferred from 70% identity to axy:AXYL_03758)

Predicted SEED Role

"Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1)" in subsystem ABC transporter oligopeptide (TC 3.A.1.5.1) or Sex pheromones in Enterococcus faecalis and other Firmicutes (TC 3.A.1.5.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (521 amino acids)

>GFF1506 ABC transporter, substrate-binding protein (cluster 5, nickel/peptides/opines) (Variovorax sp. SCN45)
MNRLLPIVAAALLATGVSASAQTLSIGFADPVSSVDPELNNHAGDRSLALHFWDSIINSR
DGGKLEPALASSWKALDDKTWEFKLRTDIKWQDGTPFSADDIVFSFQRSRNVPGSVASYS
GALRTVESVTAKDPATLIVKTNTPNPMLPLEIASIYIVSKHVGEKSKTEDYNAGRAVVGT
GPYKFVSYVPGDRTVFERNPGYYGPKPLWEKVNYRFINNGAARTAALLAGDVDVIDKVAV
TDVEKLRKDPKVSVYTYPGLRVLLLQPTFKAGPNEFITDNAGKPLEKNPLLDVRVRQALS
LAINRKAIVDRVLQGTVTEANQWMPKGSFGYNPDVKDIAYNAEQAKKLLAEAGFPQGFQI
AIHVPGDRYPQAPETVQAVAQFWSRIGVKTKVEVVPWAVYSGRANKNEYAVSVIAWGNGT
GEAGYGLLQTLTTPDAKRGRGSNNWGRYSNESVDKALDAATVEFDAKRREAIFRHAAKLV
TDDVGQIPLYHYQNIWAAKKGLKVVPLLSDRTTAMQVTPVK