Protein Info for GFF1502 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: D-galactarate dehydratase (EC 4.2.1.42)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 534 TIGR03248: galactarate dehydratase" amino acids 14 to 534 (521 residues), 901.3 bits, see alignment E=7.4e-276 PF08666: SAF" amino acids 22 to 90 (69 residues), 33.7 bits, see alignment E=6.4e-12 PF04295: GD_AH_second" amino acids 123 to 281 (159 residues), 121.1 bits, see alignment E=5.7e-39 PF20629: GD_AH_C" amino acids 290 to 531 (242 residues), 307.9 bits, see alignment E=7e-96

Best Hits

KEGG orthology group: K01708, galactarate dehydratase [EC: 4.2.1.42] (inferred from 88% identity to lch:Lcho_2484)

Predicted SEED Role

"D-galactarate dehydratase (EC 4.2.1.42)" in subsystem D-Galacturonate and D-Glucuronate Utilization or D-galactarate, D-glucarate and D-glycerate catabolism (EC 4.2.1.42)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.42

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (534 amino acids)

>GFF1502 D-galactarate dehydratase (EC 4.2.1.42) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MPETLASPPAVVPLTIRMHAADNVAIVANDGGLPAGTALPGSAVVLRDRVPQGHKVALVD
LARGAAVLRYGVPIGHALDDIPAGSWVHERLLQMPEARGLENLPMATVKPEALPPLEGYT
FEGYRNPDGSVGTRNILAITQTVQCVAGVTDFAVQRIKAELLPKFPHVDDVVALEHGYGC
GVAIDAPDAVIPIRTLRHISLNPNFGGEVMVVSLGCEKLQPERLLPPGSIPLVDERNVAD
VGTTAETRLDVVCLQDDAHVGFMSMVDSILRQAEEHLERLNARRRETVPASELVVGVQCG
GSDAFSGVTANPAVGFCTDLLVRAGASVMFSETTEVRDGIAQLTARATTPEVAQAMVREM
AWYDAYLKRGNVDRSANTTPGNKKGGLSNIVEKAMGSIVKSGSAPIANVLSPGEKLKAKG
LTYAATPASDFICGTLQLAAGMNLHVFTTGRGTPYGLAPVPVIKVATRSDLARRWHDLMD
INAGTIADGTASIEDVGWELFRLMLDVASGRQQTWAERWKLHNALVLFNPAPVT