Protein Info for GFF1467 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: L-Proline/Glycine betaine transporter ProP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 transmembrane" amino acids 36 to 56 (21 residues), see Phobius details amino acids 64 to 86 (23 residues), see Phobius details amino acids 98 to 117 (20 residues), see Phobius details amino acids 122 to 146 (25 residues), see Phobius details amino acids 167 to 188 (22 residues), see Phobius details amino acids 198 to 217 (20 residues), see Phobius details amino acids 260 to 278 (19 residues), see Phobius details amino acids 298 to 318 (21 residues), see Phobius details amino acids 327 to 346 (20 residues), see Phobius details amino acids 352 to 376 (25 residues), see Phobius details amino acids 388 to 411 (24 residues), see Phobius details amino acids 417 to 438 (22 residues), see Phobius details PF00083: Sugar_tr" amino acids 28 to 449 (422 residues), 270.3 bits, see alignment E=6.5e-84 TIGR00883: MFS transporter, metabolite:H+ symporter (MHS) family protein" amino acids 33 to 432 (400 residues), 487 bits, see alignment E=2.3e-150 PF07690: MFS_1" amino acids 61 to 309 (249 residues), 87.5 bits, see alignment E=1.8e-28 amino acids 276 to 436 (161 residues), 56.9 bits, see alignment E=3.5e-19 PF13347: MFS_2" amino acids 78 to 404 (327 residues), 35 bits, see alignment E=1.3e-12 PF08946: Osmo_CC" amino acids 454 to 499 (46 residues), 78.6 bits, see alignment 6.4e-26

Best Hits

Swiss-Prot: 100% identical to PROP_SALTY: Proline/betaine transporter (proP) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03762, MFS transporter, MHS family, proline/betaine transporter (inferred from 99% identity to sek:SSPA3815)

MetaCyc: 95% identical to osmolyte:H+ symporter ProP (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-29; TRANS-RXN-29A

Predicted SEED Role

"L-Proline/Glycine betaine transporter ProP" in subsystem Proline, 4-hydroxyproline uptake and utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (500 amino acids)

>GFF1467 L-Proline/Glycine betaine transporter ProP (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MLKRKKIKPITLGDVTIIDDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGAD
PSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYA
TIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGA
GVVVLISTIVGEENFLEWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDRE
GLQDGPKVSFKEIATKHWRSLLSCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLI
IIAIMIGMLFVQPVMGLLSDRFGRRPFVIMGSIALFALAIPAFILINSNVIGLIFAGLLM
LAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLIAGLTPTLAAWLVESSQDLMMP
AYYLMVIAVIGLITGISMKETANRPLKGATPAASDIQEAKEILGEHYDNIEQKIDDIDQE
IAELQVKRSRLVQQHPRIDE