Protein Info for GFF1422 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Alanine racemase (EC 5.1.1.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00492: alanine racemase
  • amino acids 3 to 359 (357 residues), 481.5 bits, E=7.8e-149
• PF01168: Ala_racemase_N
  • amino acids 8 to 219 (212 residues), 237.1 bits, E=1.9e-74
• PF00842: Ala_racemase_C
  • amino acids 234 to 357 (124 residues), 136.6 bits, E=3.9e-44

Best Hits

Swiss-Prot: 100% identical to ALR1_SALTI: Alanine racemase, biosynthetic (alr) from Salmonella typhi

KEGG orthology group: K01775, alanine racemase [EC: 5.1.1.1] (inferred from 100% identity to sei:SPC_4308)

MetaCyc: 91% identical to alanine racemase 1 (Escherichia coli K-12 substr. MG1655)
Alanine racemase. [EC: 5.1.1.1, 5.1.1.10]

Predicted SEED Role

"Alanine racemase (EC 5.1.1.1)" in subsystem Alanine biosynthesis or Pyruvate Alanine Serine Interconversions (EC 5.1.1.1)

MetaCyc Pathways

• L-alanine degradation I (2/2 steps found)
• alanine racemization (1/1 steps found)
• anaerobic energy metabolism (invertebrates, cytosol) (5/7 steps found)
• vancomycin resistance II (1/3 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (10/17 steps found)
• L-arginine degradation XIV (oxidative Stickland reaction) (2/6 steps found)
• L-lysine degradation V (2/9 steps found)
• ansatrienin biosynthesis (1/9 steps found)
• cyclosporin A biosynthesis (2/15 steps found)
• superpathway of L-lysine degradation (14/43 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Cysteine metabolism
• D-Alanine metabolism
• D-Arginine and D-ornithine metabolism
• D-Glutamine and D-glutamate metabolism
• Glycine, serine and threonine metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.1.1.1

Use Curated BLAST to search for 5.1.1.1 or 5.1.1.10

Protein Sequence (359 amino acids)

>GFF1422 Alanine racemase (EC 5.1.1.1) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MQAATVVINRRALRHNLQRLRELAPASKLVAVVKANAYGHGLLETARTLPDADAFGVARL
EEALRLRAGGITQPILLLEGFFDAADLPTISAQCLHTAVHNQEQLAALEAVELAEPVTVW
MKLDTGMHRLGVRPEEAEAFYQRLTHCKNVRQPVNIVSHFARADEPECGATEHQLDIFNA
FCQGKPGQRSIAASGGILLWPQSHFDWARPGIILYGVSPLEHKPWGPDFGFQPVMSLTSS
LIAVRDHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPRAAPSGTPVLVNGREVPIVGR
VAMDMICVDLGPNAQDNAGDPVVLWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYID