Protein Info for GFF1370 in Pseudomonas sp. DMC3

Annotation: HTH-type transcriptional regulator DmlR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 311 PF00126: HTH_1" amino acids 10 to 68 (59 residues), 70.4 bits, see alignment E=9.8e-24 PF03466: LysR_substrate" amino acids 93 to 300 (208 residues), 133.5 bits, see alignment E=6.9e-43

Best Hits

Swiss-Prot: 31% identical to LTRA_KLEPN: Probable HTH-type transcriptional regulator LtrA (ltrA) from Klebsiella pneumoniae

KEGG orthology group: None (inferred from 93% identity to pfo:Pfl01_3767)

Predicted SEED Role

"FIG032225: Transcriptional regulator, LysR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (311 amino acids)

>GFF1370 HTH-type transcriptional regulator DmlR (Pseudomonas sp. DMC3)
MHGLNELGFKALRLFVAVLDHGSFSEVARREGVSPSSISRQIQLMEQALNQQLLYRHTRA
VTPTEAGRTLGHHARLLLVQLEEAEQALQEQQSEPTGLVRINAPVVFGQRHLTPWLGQLC
ARYPKLQLDIQQTDHYVDPLQEGADLLFRIGALHDSSMQARILAPHRFQVAASPAYLKRH
GTPQHPDELAQHQCLAYKGAAGQQRWFFRRDGEDWTPYTVKGPITGNHADTLTQAAQQGL
GLVMFPSWLIGEAVREGTLMPVLREYQVSNSLEPQQIAVLWPGSRRLSVKVRTVIDFFVE
CFGEIPYWDRA