Protein Info for GFF135 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Transcriptional regulator, AsnC family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 159 PF13412: HTH_24" amino acids 7 to 54 (48 residues), 50.1 bits, see alignment E=3.1e-17 PF13404: HTH_AsnC-type" amino acids 7 to 47 (41 residues), 56.5 bits, see alignment E=4e-19 PF01037: AsnC_trans_reg" amino acids 70 to 150 (81 residues), 67.3 bits, see alignment E=1.7e-22 PF22482: AsnC_trans_reg_3" amino acids 85 to 143 (59 residues), 24.8 bits, see alignment E=4.1e-09

Best Hits

Swiss-Prot: 32% identical to REG6_PYRHO: Uncharacterized HTH-type transcriptional regulator PH1519 (PH1519) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)

KEGG orthology group: K03719, Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein (inferred from 43% identity to sna:Snas_3176)

Predicted SEED Role

"Transcriptional regulator, AsnC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (159 amino acids)

>GFF135 Transcriptional regulator, AsnC family (Hydrogenophaga sp. GW460-11-11-14-LB1)
MQANINIDDTDARILTVLSADSRRSYAEVAAEVGLSTAAVHERVKKMAERGVIERFALRV
DPDRVGLRFTAFVAIRNDGGAHCREIAPRLSALPEVLELHSVAGEHDFIAKVRTTHARAL
EDVLYRIKAIPGVARTTSTVVLNTEFEDRPLQLPGDRPA