Protein Info for GFF1346 in Methylophilus sp. DMC18

Annotation: Motility protein A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 285 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 29 to 48 (20 residues), see Phobius details amino acids 171 to 188 (18 residues), see Phobius details amino acids 200 to 225 (26 residues), see Phobius details TIGR03818: flagellar motor stator protein MotA" amino acids 1 to 281 (281 residues), 403.9 bits, see alignment E=1.5e-125 PF20560: MotA_N" amino acids 4 to 93 (90 residues), 119.6 bits, see alignment E=5.4e-39 PF01618: MotA_ExbB" amino acids 129 to 238 (110 residues), 46.3 bits, see alignment E=3.5e-16

Best Hits

Swiss-Prot: 57% identical to MOTA_SALTY: Motility protein A (motA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K02556, chemotaxis protein MotA (inferred from 82% identity to mmb:Mmol_1262)

Predicted SEED Role

"Flagellar motor rotation protein MotA" in subsystem Flagellar motility or Flagellum

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (285 amino acids)

>GFF1346 Motility protein A (Methylophilus sp. DMC18)
MLVIVGYVVILGAIFGGYAAAGGHLGGLWQPLEVVMIFGGAVGAFVVGNDAKSLKATLKD
LPNAFKGSHVNKAMYMDLLALLFEILTKIRKEGLMSIEKDVEDPESSALFGKYPKIQHDH
HVVEFICDYLRLMVSGNMDAFQVENLMDNEIETHHQEGHVAAHCIAKLGDALPAFGIVAA
VMGVVHTMESLHLPPTELGVLIGHALVGTFLGILLAYGFVGPLAGVLEAKLEESSKVFQT
IKVTLLASLNGYAPAIAVEFGRKVLYSTERPSFSELEDYVKQAKK