Protein Info for GFF1323 in Variovorax sp. SCN45

Annotation: Methionine aminopeptidase (EC 3.4.11.18)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00500: methionine aminopeptidase, type I
  • amino acids 6 to 258 (253 residues), 291.9 bits, E=2e-91
• PF00557: Peptidase_M24
  • amino acids 12 to 250 (239 residues), 185.6 bits, E=5.1e-59

Best Hits

Swiss-Prot: 54% identical to MAP1_ECO57: Methionine aminopeptidase (map) from Escherichia coli O157:H7

KEGG orthology group: K01265, methionyl aminopeptidase [EC: 3.4.11.18] (inferred from 97% identity to vap:Vapar_2941)

MetaCyc: 54% identical to methionine aminopeptidase (Escherichia coli K-12 substr. MG1655)
Methionyl aminopeptidase. [EC: 3.4.11.18]

Predicted SEED Role

"Methionine aminopeptidase (EC 3.4.11.18)" (EC 3.4.11.18)

MetaCyc Pathways

• Arg/N-end rule pathway (eukaryotic) (8/14 steps found)
• Ac/N-end rule pathway (6/21 steps found)

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.18

Use Curated BLAST to search for 3.4.11.18

Protein Sequence (274 amino acids)

>GFF1323 Methionine aminopeptidase (EC 3.4.11.18) (Variovorax sp. SCN45)
MSINYKDAAGIEAMRVACRLASEVLDYLTPLIKPGITTNDVDRLAAEYMVKQGTTSATVG
YMGASSVPFPKSLCTSVNHVVCHGIPNDKPLKKGDIMNVDVTVIKDGWFGDNSRMYVIGD
TSIAAKRLCNITFEAMWHGILQVRPGAHLGDVGHAIQKFAEGQGFSVVREFCGHGVGQRF
HEEPQVLHYGRPGTLEELKPGMIFTIEPMINAGKRDVKEDFKGGQYDGWTIVTRDHSLSA
QWEHTVLVTETGYEVLTLSAGSPPLPSFVTSTKT