Protein Info for GFF1322 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Galactose operon repressor, GalR-LacI family of transcriptional regulators

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 339 PF00356: LacI" amino acids 3 to 48 (46 residues), 67.7 bits, see alignment 1.2e-22 PF00532: Peripla_BP_1" amino acids 60 to 285 (226 residues), 106.2 bits, see alignment E=4.4e-34 PF13407: Peripla_BP_4" amino acids 62 to 310 (249 residues), 65.5 bits, see alignment E=1.2e-21 PF13377: Peripla_BP_3" amino acids 169 to 329 (161 residues), 107.3 bits, see alignment E=1.9e-34

Best Hits

Swiss-Prot: 41% identical to ASCG_ECOLI: HTH-type transcriptional regulator AscG (ascG) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to stm:STM3012)

Predicted SEED Role

"Galactose operon repressor, GalR-LacI family of transcriptional regulators" in subsystem Lactose and Galactose Uptake and Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (339 amino acids)

>GFF1322 Galactose operon repressor, GalR-LacI family of transcriptional regulators (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MATMLDVSRHAGVSKATVSRVLNGTGQVKESTRQKVFTAMQALGYRPNLLARSLANRTSN
SIGLVVSTFDGFYFGSLLRRASRQAESHNKQLIVTDGHDTPEREQKAVQMLADRQCDAII
LYTRYMDELAILSLIDATEMPLVIINRNVTQARDRAIFFEQETAAFQAVEYLITQGHRDI
ACITLPVHTPTGTSRVAGYRKALEKYGIPWQPAKVKYGDYTLTRGYDACRELLEEGVTFS
ALFACNDDTALGAAKALRQAGLRIPQDVSLFGFDDAPGATWLEPGLSTVYLPIEAMIATA
IDQAVRLANSEPVAPIPPFTGTLILRESVAAGPFFQRPA