Protein Info for GFF1318 in Xanthobacter sp. DMC5

Annotation: putative zinc protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 421 PF00675: Peptidase_M16" amino acids 21 to 160 (140 residues), 135.2 bits, see alignment E=1.7e-43 PF05193: Peptidase_M16_C" amino acids 167 to 338 (172 residues), 135.7 bits, see alignment E=1.7e-43

Best Hits

Swiss-Prot: 38% identical to Y522_RICBR: Uncharacterized zinc protease RBE_0522 (RBE_0522) from Rickettsia bellii (strain RML369-C)

KEGG orthology group: None (inferred from 88% identity to xau:Xaut_3525)

Predicted SEED Role

"Mitochondrial processing peptidase-like protein (EC 3.4.24.64)" in subsystem ZZ gjo need homes (EC 3.4.24.64)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.24.64

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (421 amino acids)

>GFF1318 putative zinc protease (Xanthobacter sp. DMC5)
MSVKISTLDNGITVITDEMSHLGTASLGIWVGAGARDEKGDEHGISHLLEHMAFKGTRRR
SARRIAEEIEQVGGDINAATSVEQTTYNVRVLGEDVGLGIDILADILTEPAFAPDELERE
KNVIVQEIGAVMDTPDDLVFDLFQEQAFPGQSVGRSILGTPETVRGFSRDQLGAYLGRTY
RGPRMVVSAAGAVEHDRLVDEAAARLSGVGNGVAPDLSPATYAGGTRLTARDLEQVHILM
GLEGCSYKDADYHALQVLSNVLGGGMSSRLFQDVREERGLCYSIYAFHWSYQDTGLFGIY
AGTDTGDVEELSHAVVDQIFDTAETVTELEVARAKAQMKVGLLAALESSGARADQLARQI
LGFGRVIPVEEIVAKVEAVDVVAVRAAASRLIGRGRPTLSVIGPKGGLEPAARVVQRLSG
H