Protein Info for PS417_06695 in Pseudomonas simiae WCS417

Annotation: 4-hydroxybenzoate transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 transmembrane" amino acids 28 to 50 (23 residues), see Phobius details amino acids 63 to 82 (20 residues), see Phobius details amino acids 93 to 112 (20 residues), see Phobius details amino acids 119 to 140 (22 residues), see Phobius details amino acids 151 to 172 (22 residues), see Phobius details amino acids 178 to 202 (25 residues), see Phobius details amino acids 251 to 280 (30 residues), see Phobius details amino acids 299 to 319 (21 residues), see Phobius details amino acids 328 to 344 (17 residues), see Phobius details amino acids 350 to 368 (19 residues), see Phobius details amino acids 388 to 412 (25 residues), see Phobius details amino acids 419 to 440 (22 residues), see Phobius details TIGR00895: MFS transporter, aromatic acid:H+ symporter (AAHS) family" amino acids 11 to 410 (400 residues), 524.1 bits, see alignment E=1.2e-161 PF07690: MFS_1" amino acids 33 to 286 (254 residues), 121.2 bits, see alignment E=7.4e-39 amino acids 266 to 432 (167 residues), 48.4 bits, see alignment E=1e-16 PF00083: Sugar_tr" amino acids 36 to 227 (192 residues), 89.7 bits, see alignment E=3e-29 PF06779: MFS_4" amino acids 49 to 206 (158 residues), 36.5 bits, see alignment E=5.8e-13

Best Hits

Swiss-Prot: 90% identical to PCAK_PSEPU: 4-hydroxybenzoate transporter PcaK (pcaK) from Pseudomonas putida

KEGG orthology group: K08195, MFS transporter, AAHS family, 4-hydroxybenzoate transporter (inferred from 97% identity to pfs:PFLU1362)

Predicted SEED Role

"4-hydroxybenzoate transporter" in subsystem Cinnamic Acid Degradation or Gentisare degradation or Phenylpropanoid compound degradation or Salicylate and gentisate catabolism or p-Hydroxybenzoate degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7TYY3 at UniProt or InterPro

Protein Sequence (446 amino acids)

>PS417_06695 4-hydroxybenzoate transporter (Pseudomonas simiae WCS417)
MNQPSVGTPLDVQSFINAQPLSRYQWRVVILCFLIVFLDGLDTAAMGFIAPALSQDWGID
RASLGPVMSAALIGMVFGALGSGPLADRFGRKVVLVGAVLVFGAFSLASAYSSNVDQLLV
LRFLTGLGLGAGMPNATTLLSEYTPERHKSLLVTSMFCGFNLGMAGGGFISAKLIPAFGW
HALLLIGGILPLILVVVLMLWLPESARYLVVRNRGTDKVRKTLSPIDPVIVGQATSFSVP
EQKTVKARNVFAVIFSGTYSAGTLLLWLTYFMGLVIVYLLTSWLPTLMRDSGASLEQAAF
IGALFQFGGVLSAVGVGWAMDRFNPHKVIGSFYLLAGVFAYAVGQSLGNITLLATLVLIA
GMCVNGAQSAMPSLAARFYPTQGRATGVSWMLGIGRFGAILGAWMGATLLGLGWNFEQVL
TALVIPAALATAAVVIKGMVSHADAT