Protein Info for PS417_06690 in Pseudomonas simiae WCS417

Annotation: IclR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 280 TIGR02431: beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family" amino acids 31 to 278 (248 residues), 351 bits, see alignment E=1.6e-109 PF09339: HTH_IclR" amino acids 36 to 87 (52 residues), 55.3 bits, see alignment 4.6e-19 PF01614: IclR" amino acids 152 to 276 (125 residues), 137.8 bits, see alignment E=2e-44

Best Hits

Swiss-Prot: 86% identical to PCAR_PSEPU: Pca regulon regulatory protein (pcaR) from Pseudomonas putida

KEGG orthology group: K02624, IclR family transcriptional regulator, pca regulon regulatory protein (inferred from 99% identity to pfs:PFLU1361)

Predicted SEED Role

"Pca regulon regulatory protein PcaR" in subsystem Protocatechuate branch of beta-ketoadipate pathway

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U387 at UniProt or InterPro

Protein Sequence (280 amino acids)

>PS417_06690 IclR family transcriptional regulator (Pseudomonas simiae WCS417)
MNDQLRNSFASVAPPIVASPAKRIQAFTGDPDFMTSLARGLAVVQAFQERKRHLTIAQIS
HRTEIPRAAVRRCLHTLIKLGYATTDGRTYSLLPKVLTLGHAYLSSTPLAVSAQPYLDRM
SEQLHEACNMATLEGDDILYIARSATTQRLISVDLSVGGRLPAYCTSMGRILLAALDDAS
LQDYLDHADLQTKTSRTLTTPAALFECLQQVRQQGWCIVDQELEQGLRSIAVPVYDASGQ
VLAALNVSTHAGRVSRSELEQRFLPNMLSASRELSAQLFA