Protein Info for GFF1304 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: FIG146285: Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 120 PF11969: DcpS_C" amino acids 7 to 112 (106 residues), 82 bits, see alignment E=4.7e-27 PF01230: HIT" amino acids 16 to 113 (98 residues), 83 bits, see alignment E=2e-27

Best Hits

Swiss-Prot: 48% identical to HITA_NEIGO: Protein HitA (hitA) from Neisseria gonorrhoeae

KEGG orthology group: None (inferred from 80% identity to xtr:100493705)

MetaCyc: 43% identical to purine nucleoside phosphoramidase (Escherichia coli K-12 substr. MG1655)
3.9.1.-

Predicted SEED Role

"FIG146285: Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (120 amino acids)

>GFF1304 FIG146285: Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSAHDPNCIFCKIIAGQIPSKKVYEDEDIYVFHDIHPWAPVHFLMVPKAHIPSMAQLGPE
HERLMGRIMTLAPRLALEQGCNPYPEGGFRIVCNNGAEGGQEVHHLHVHVMGGPRPWLRG