Protein Info for GFF129 in Sphingobium sp. HT1-2

Annotation: Propionyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.3)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01039: Carboxyl_trans
  • amino acids 29 to 508 (480 residues), 665.9 bits, E=3.5e-204
• PF03255: ACCA
  • amino acids 309 to 416 (108 residues), 37.1 bits, E=2.1e-13

Best Hits

Swiss-Prot: 75% identical to PCCB_RHOS4: Propionyl-CoA carboxylase beta chain (pccB) from Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

KEGG orthology group: None (inferred from 98% identity to sch:Sphch_0764)

MetaCyc: 75% identical to propionyl-CoA carboxylase beta subunit (Cereibacter sphaeroides)
Propionyl-CoA carboxylase. [EC: 6.4.1.3]

Predicted SEED Role

"Propionyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.3)" in subsystem Propionyl-CoA to Succinyl-CoA Module or Serine-glyoxylate cycle (EC 6.4.1.3)

MetaCyc Pathways

• propanoyl CoA degradation I (3/3 steps found)
• 3-hydroxypropanoate cycle (10/13 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (7/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (12/17 steps found)
• methylaspartate cycle (13/19 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (12/18 steps found)
• superpathway of the 3-hydroxypropanoate cycle (12/18 steps found)
• superpathway of L-methionine salvage and degradation (8/16 steps found)
• mycolate biosynthesis (23/205 steps found)
• superpathway of mycolate biosynthesis (24/239 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.3

Use Curated BLAST to search for 6.4.1.3

Protein Sequence (510 amino acids)

>GFF129 Propionyl-CoA carboxylase carboxyl transferase subunit (EC 6.4.1.3) (Sphingobium sp. HT1-2)
MSKLAIIEQLEAKREGARMGGGQRRIDAQHGKGKLTARERIEVLLDEDSFEELDMYVEHN
CIDFGMDEQHIPGDGVVTGSGTINGRLVYVFSQDFTVYGGAVSERHAMKICKIMDIAMKV
GAPVIGLNDSGGARIQEGVASLAGYAEIFQRNVLASGVVPQISVIMGPCAGGAVYSPAMT
DFIFMVKDSSFMFVTGPDVVKTVTNEVVTQEELGGAITHTTKSGVADVAFENDIEALLAV
RDFVDFLPASNKEPVPERPSADPWDRLEDSLDTLIPANANQPYDMHELIRKVVDEGDFFE
VQPAHAGNILCGFGRIEGKTVGIIANQPMVLAGVLDINSSKKAGRFVRFCDAFEIPIVTF
VDVPGFLPGTAQEHSGIIKHGAKLLFAYAEATVPKITVITRKAYGGAYDVMSSKHLRGDL
NYAWPTAEIAVMGAKGAVEIIFRGKTPEEIAEKTKEYEDRFANPFVAASKGFIDEVIQPH
STRKRIALGLRKLKNKALENPWKKHDNIPL