Protein Info for GFF1270 in Variovorax sp. SCN45

Annotation: Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 500 1000 1500 2000 2500 3000 3500 4000 4500 5052 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details TIGR01643: YD repeat (two copies)" amino acids 164 to 202 (39 residues), 21.2 bits, see alignment (E = 1.5e-08) amino acids 291 to 324 (34 residues), 19.5 bits, see alignment (E = 5.4e-08) amino acids 356 to 393 (38 residues), 30.7 bits, see alignment (E = 1.6e-11) amino acids 377 to 412 (36 residues), 16.7 bits, see alignment (E = 4e-07) amino acids 741 to 772 (32 residues), 15.9 bits, see alignment (E = 7.6e-07) amino acids 1643 to 1678 (36 residues), 28.5 bits, see alignment (E = 7.7e-11) amino acids 1746 to 1781 (36 residues), 17.7 bits, see alignment (E = 2e-07) amino acids 1891 to 1931 (41 residues), 18.9 bits, see alignment (E = 8.2e-08) amino acids 1912 to 1953 (42 residues), 29.4 bits, see alignment (E = 4.1e-11) amino acids 1975 to 2010 (36 residues), 25.1 bits, see alignment (E = 9.4e-10) amino acids 2017 to 2054 (38 residues), 16.5 bits, see alignment (E = 4.6e-07) amino acids 2062 to 2094 (33 residues), 26.5 bits, see alignment (E = 3.2e-10) amino acids 2112 to 2141 (30 residues), 18.4 bits, see alignment (E = 1.2e-07) amino acids 2157 to 2196 (40 residues), 17 bits, see alignment (E = 3.3e-07) amino acids 2891 to 2928 (38 residues), 27.3 bits, see alignment (E = 1.9e-10) amino acids 2934 to 2962 (29 residues), 17.6 bits, see alignment (E = 2.1e-07) amino acids 2996 to 3023 (28 residues), 22.7 bits, see alignment (E = 5.2e-09) PF05593: RHS_repeat" amino acids 165 to 198 (34 residues), 22.6 bits, see alignment (E = 1.1e-08) amino acids 328 to 371 (44 residues), 25.5 bits, see alignment (E = 1.4e-09) amino acids 542 to 576 (35 residues), 23.1 bits, see alignment (E = 7.8e-09) amino acids 1643 to 1679 (37 residues), 39.7 bits, see alignment (E = 4.9e-14) amino acids 1725 to 1760 (36 residues), 28.6 bits, see alignment (E = 1.5e-10) amino acids 1912 to 1945 (34 residues), 25.7 bits, see alignment (E = 1.2e-09) amino acids 1933 to 1969 (37 residues), 26.4 bits, see alignment (E = 7.5e-10) amino acids 1976 to 2010 (35 residues), 29 bits, see alignment (E = 1.1e-10) amino acids 2017 to 2054 (38 residues), 25.6 bits, see alignment (E = 1.3e-09) amino acids 2062 to 2093 (32 residues), 28.5 bits, see alignment (E = 1.6e-10) amino acids 2112 to 2148 (37 residues), 26.8 bits, see alignment (E = 5.6e-10) amino acids 2891 to 2927 (37 residues), 33.7 bits, see alignment (E = 3.8e-12) amino acids 2996 to 3031 (36 residues), 25.7 bits, see alignment (E = 1.2e-09) PF16640: Big_3_5" amino acids 808 to 888 (81 residues), 48.8 bits, see alignment (E = 8.4e-17) amino acids 1297 to 1381 (85 residues), 59.3 bits, see alignment (E = 4.7e-20) amino acids 1404 to 1476 (73 residues), 36.9 bits, see alignment (E = 4.5e-13)

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (5052 amino acids)

>GFF1270 Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA (Variovorax sp. SCN45)
MVAIVSGNSLGLSLGSLATLGGRGGVGSAQQGRNGESAYVNVANGNLVLQDLDDRLVGRG
LDIATVRTYNSQGLFDDDNGDNWRVGAHGQKVVLTGTAGTAGSTLARTDRDGATAVYAWS
ASRNLYVSSAGAGAFDTIAYDAANARYVWTDGSSGLVERYDASGQGRLLFAVDPNGNTVS
YSYNANGTLKSVVDANGEATYFDYTGTNLTQVRTVATGGATLTRVRYAYDGANRLSSVTV
DLSPEDNSVADGKTYVTTYNYDGTSKRVASVTQSDGTALAFTYVLSGSSYKVATVTDALG
QITRFAYDSASSTTTVTDPQGARSTFLYDADGNLLQVRQGVTAGNAAGLSQVSYRYDAAG
NVTGMTDGEGRELAYEYDANGNLLKEVDSAGNTHTRTYNSANQLLSDTIYADASVSRGVF
SKDAALPETTRYVYAPGNALQLRFVVTAQGNVTEHRYDSYGQRISTIRYVGSAYGVSTLG
TTDVPTQAQMLAWLGGQDPSRTERVDYAYDARGSLSSATTYGEVDATGAGTTATAARTQY
VYDQHGNLLQKIEPSGGGTTTYVYDGLGRVLSVSAPSLDGVTANTTVTSYDDAGGRTSVT
VASGLVSISAYDKAGRLVSVTQQSAGSGVLGTTTYAYDKNGNLLMTQDPTGVRKWMLYDE
ANRKIAEIDATGALVEYVYNASGQLRQSVAYATKLTAQKLAQLLDGAGKPTTAWAADNTT
TSLATLRPATAAQDQRVWRFYDNVGRLTWQVDALGYVTQTTYDGASRILAVTQLAKPIDV
APLLKGANIDLGVDPSTLGGISLSVNNAESTSYGLIAVLTASVDGAGLRGMVTFFDGETV
IGSAVVVDGKATLATDRMSIGTHNLRVAYSGDDLRPASVSKAVKKTITPILTTATLGVQR
NPSAGSRSVILSVDVKMPDSAGDWGWLMPSGQITFYAGNKIIGSIVLSNGFGNLVVNDLP
EGMQTLRAEYSGDILHAPTVSTPRIFSAKPIPTEATLTSSKNVDGSSTLTARITVPAGST
YLPTGSVTFYSGQSVLGISTLVDGRATFKVNQLGATGPFTVAYAGNVDYAASANKRSPTS
LIVSVDPWLPTTNLLNVRLHVAGVGYGATGALYIFGGNSVGLGTGYFVNAEGTTNIWVER
SALIKAGGILNIAYTGDSKFQSCILSLKLNLSPSLNPERDAYTAFTVSQQINQSIGVSES
FAGFNPAITVKGEGVWDDRFYFDGQILTSTVNHYLEARGLADPDTARLPVNLAKGLHDLT
VISLVVEQTDDLPIFIGQRSSQSIAITRTKSQVNLFSSKQSVGAGESVTLTAAIQATPNS
PNIPRANGAVTFCRNGIAIGTGTLMNGVATLSIGSLPVGTAKFTASYAGDDNYLASQTTA
DSWVQVAGSPVVLTNLTTPVIAKDGALSVRVVGKTAATGLVSFYSGMTLLGTVAVTADGT
ATLRGVPIPAGTHTFSAAYSGDEANADGAITFTQTVEGTPDTPRVLVGLDITQDRTVTQL
LNRNGQVQGTLDAEGYLTEYKYNAAGEQVQSIRYANRAANFASVSARLMAVAIARASGDL
AGVRPAASDGDIRTYTFYNARGQAVGQVDGEGYLTETVYDARGNVTQTRRYASLARNPGS
ANATLASVRPDPSAQDQSITQTWSAANQLLSRTNAEGTVTTFTYDVAGRLVQTTTAAGTP
DERIQRLRYDIQGHLIAELDGRGSDAVALNAPLASWSANGSTHAYDAAGRRTGTTDANGH
RTLFFYDAFGRLAYTVNALGEVTESRYNAYGQVSEQIVYGSRIDLTPLGTATPGGLNTDA
LKALLATMADPAKDTHVLKTYNASGTLTSSTDAMGGVTSYAYNAFREAIASSRTRLSGQV
ITNTVTFDRRGLQVSTTSDATGAGLTRRTGYDAFGRPDTRIDGNGNTASLRYDRLGRVVA
TTDATGATRTTTYDAFDRVLTQRDALNNVTSYAYSVANRSVTVTTPEGVSVTTLHNRQGQ
TTSVTDGRGNTTTYSYDKSGNLLRTQAPEGVGTSTTYDKIGLKLSTTDARGTVTTYGYDA
VSRLLTRTVDPGGLTLVTSYLYDAKGQTISVTDPGGTVTTTAYDLNGQVVRQTLDPSNGA
YVGLKLETVYTHDSDGTALSVHGPDGRLTRYTYDGAGRRIKEQVDPLGLNLTRSYAYDAE
GNVIKAVDASGNATLFIYDQAKRLAFTIDAMGGVQQSGYDAEGRLSSQTTYAAFVPVAAW
NGTAPSLSAMQAALPTLGLAATQSRRYDRDGRLRFAVDATGAVVEYRYDDAGNVVESRAY
AQRIELGKWHGAIDPPVVADDAHDQRSRSVYDALGRKTHSIDGTGAVVRQVFDASGNVTE
RFAYSKRVPAATAATTDALAAAVALVAEPARDPHDTYVYDRAGRQLLHTDGVGKVTSQNY
DKSGNIISRAYINDQPAGTNLFTHSEFANGLRDTENWIGAVRASQMEGFAGALRIGVDPR
EGYAGAYKLHQSLTLGATYTMSVVVEMEDGLPPSFGSTNARDAANSFAFASLGRMADPLA
YTVQHLGGKQYRVATTGVASGEMAYFGVVKFTSNDPRPLRVTGYQLEQTDVASNITPTTA
TPVLIAAKTQSQVTRFAYDSAGRLVYTLGPLGQLEKNSYDGAGRITLTTRYARPVSTKGL
GAAPTVAQLQALASQTPGQDQQQFNVYDQGGRLSATVDAMGSVVTFKRDGNGSVSERTAW
ANTVDMNKWAPDTAPVPKADTARDQHTRIFYDAMGRETLTIDALGYAVQRQYDAQGRPSY
VVRYPVAVPASTPNTQKAKLDAAIALASVSGRPLQITAYGYDAAGNRTSQTEALGQPEAA
TTQYVFDGIGRLTRTIDARGVELSQSDSAWALTQRLQLKYVNAAGGALKASDLSQAQRQA
LAARYTTTIDYDAAGHKLSVTDALGGVTRSDYDANGRVVRITDPRGNSAFYYFDAAGRVT
LSVDPEGYATATTYDALGHTLSVKRHFNRVSGTYKIAQPPALPGANPSDALTRFEYDASG
RLTRTIDAQSNAERYTYNALGQRETLTNKLGGLTAYTYDQLGRVASETLPITSRNAAGQS
VAVRNQYAYDAFGNRATTTEAVGLPEQRVTQFSYDGLNREVEQRQAQVRIYVDGQGWSTI
APTRTRSYDASGNLIAVVEPNGGRTRTWFDGTNRKVAEVSATGTLSTWSYDATGNVMAQR
VYGDALILPVGDALPTPVNAANVRLTTYQVDANNRVLSSTIAGIQSGNYDASGHQYNMAV
TSDLVNRSFYDANGNVVREHNGKDAATLTWYDRLGQKLLQVDAMGFGVRWERDANGAVLR
ETRFAKEIVLGSLSESTSVDAVLQKFTPGLNDQITEYSYDRNARVRSESRLNVAYGRVAA
NGALSEGATSATQRTEYNAMGNKTATIDAQGQRSEMRYDTIGRLLSVQRPGAADFNGNAV
RQVTDYELNGLGNVRREIRRGTDNAVESDDEIVRYGYDATGVRTSMTTAKGETVTYGRDA
NGNTTAQMTDRVDADGAVSRDIVSIAYDAANREARRFTGGRDAADMPVFDAANTITLTYN
AWGELASKRTGSGNAQGQAQEYYDYDKAGRLWRTNSKGGVNKAWMYDLAGNATLQLESQR
VDLRAMTWDQMAGDGSHPNPDILITITSYDKDNRVVSVMQPKMDAARPNLKMFAAPINVD
SGKFGGLDIDVAPALAEANSTWIAGPSDGSATGAVSVLGMPILGGNIRPITNGEAGIPGN
PRHVSDVVVGVTDLLIGSAGDWTSNIENIYGAMTWRIEVAGTTQFLGRVTTWPQVVHPMY
NTPPFPVVSMYMHRGLAYSGLMPIRVIATVQSSGLDVVVSTGTIRQLPWPTQDQTLSGTF
MRLTASEARDTDTIQLYSRPRDSNSPFSQSLPIFKAGQGGSSLNNVAIDGSYFTRLESLG
GPTELLLVVTQPDGTVVRRQSIQYDPATRQSSSSVAAAQPVFTTDNVAHFTGMRINGHAI
RVLQRPNGSEGEYSQRTYWPAGATGRFEVQFDGGTSDVIIEVLDMGRNVVVDRLKGTVNP
GVSYYDMRPLAALPSSITFRDIPIDAQTLQIDYEPLSPGGLKGSITIPRERAGDIAQWVW
DAANLIPDKRSLYSYRLHAVARDADGFIMTDITGEATIGALSKIGTKARLTGNLKHQVMT
FDPEISEGRSMKLRYRDKGATDKDFTEVAATRVKIGTAFKWDATANGLNPDKEYEFLYDV
YNASGAMIGNGEGYFRLNNTTANSDVRWAIPNLPGQDIINHSWVIQRRQEHDAFGRVVKE
IDGKENVNDLRYNTLGLLIDKIGPVVDVTLANGQRQAIRPTEHYSYDLNGQFVGKRDANG
NQSTVQINAAGQAVAEWHPGATAGTSAVVRKAYDVFGNLRTVTDEIGRVTRNEYDFNNRL
KRVERPVNANGSVAVDAYEYDILGQRIAQVNALDYRVRTYYDSMGRVTRYISAEGATVNY
GYTYDNSIGSAGGVNTGGWTNTTTDANGRTQTLKNDVFGRTMWKQDLGGHQFTYGYNWSG
LIATQTGNSGQNIAYSYYDNGYLRKVSDAGVSTESIFEYDNNGNRIFEGLKAITGNVVFQ
WSRVSYDAYNRVKTIDDARYMINYEYDANGNRRRVLSTYINVVDQRKDVQDYWYAYDGMN
RFTTTMGQMVNGQIWRGASGDGVTIEYDNAGQRKAAIYARDGHREDYDYDGTGHLTAMKM
NGVLRSRRTNDLAGRVTRYEELYADQTLSSQKDRTWNKDNQLTVEVERRLTEGTNGRKWS
DTTTAYTLMQDGTLSKVDSLTNAFNNFNPSAQDPAVVITRMISNYAYDWWDSAKQTSITL
DPVSTGYDPKRPQPPGYSVFGYDVNGHLKTATDLNATTPRSFSYWTNAEGQVLQRQELIG
GKIGADGNVSGASKSRDHRYFYFDGKRVGNVGNDGVEREDYAQQLARSSATQSPDDKYRK
FTPTNSADFDENYQPINAGFPGPAPGSYTVREGDTLEGVARALWGDATLWYLLAEANGLD
GQPSAALVENTVLQVPNKVTNLHNTSSTFRPYDPGKAMGDTSPTLPDPLPAPKGKGGDAE
GWAQSSWRSSLW