Protein Info for PS417_06290 in Pseudomonas simiae WCS417

Annotation: acetyl-CoA carboxylase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00513: acetyl-CoA carboxylase, carboxyl transferase, alpha subunit
  • amino acids 2 to 314 (313 residues), 512.6 bits, E=2.3e-158
• PF03255: ACCA
  • amino acids 5 to 314 (310 residues), 489.3 bits, E=4.5e-151
• PF01039: Carboxyl_trans
  • amino acids 97 to 245 (149 residues), 62 bits, E=4.6e-21

Best Hits

Swiss-Prot: 99% identical to ACCA_PSEFS: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA) from Pseudomonas fluorescens (strain SBW25)

KEGG orthology group: K01962, acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC: 6.4.1.2] (inferred from 99% identity to pfs:PFLU1286)

MetaCyc: 69% identical to acetyl-CoA carboxyltransferase subunit alpha (Escherichia coli K-12 substr. MG1655)
RXN0-5055 [EC: 2.1.3.15]

Predicted SEED Role

"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (49/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• biotin-carboxyl carrier protein assembly (4/4 steps found)
• fatty acid biosynthesis initiation (type II) (3/3 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• propanoyl CoA degradation I (2/3 steps found)
• 2-oxobutanoate degradation I (2/4 steps found)
• fatty acid biosynthesis initiation (type I) (1/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (5/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (9/17 steps found)
• candicidin biosynthesis (1/6 steps found)
• 3-hydroxypropanoate cycle (6/13 steps found)
• jadomycin biosynthesis (3/9 steps found)
• superpathway of L-methionine salvage and degradation (8/16 steps found)
• methylaspartate cycle (10/19 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (9/18 steps found)
• superpathway of candicidin biosynthesis (3/11 steps found)
• glyoxylate assimilation (4/13 steps found)
• superpathway of the 3-hydroxypropanoate cycle (6/18 steps found)
• superpathway of mycolate biosynthesis (21/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tetracycline biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.2

Use Curated BLAST to search for 2.1.3.15 or 6.4.1.2

Sequence Analysis Tools

See A0A1N7UBD2 at UniProt or InterPro

Protein Sequence (315 amino acids)

>PS417_06290 acetyl-CoA carboxylase subunit alpha (Pseudomonas simiae WCS417)
MNPNFLDFEQPIADLQAKIEELRLVGNDNSLNIGDEIARLQDKSSSLTEDIFGKLTSWQI
ARLARHPRRPYTLDYIQHIFTEFDELHGDRHFSDDAAIVGGIARLDDQPVMVIGHQKGRE
VREKVRRNFGMPRPEGYRKACRLMEMAERFKMPILTFIDTPGAYPGIDAEERNQSEAIAW
NLRVMARLKTPIIATVIGEGGSGGALAIGVCDQLNMLQYSTYAVISPEGCASILWKTAEK
APDAAEAMGITADRLKGLGIVDKVIAEPLGGAHRDPAAAAATIRAELGSQLAMLKKLDNE
ALLARRYERLMSYGL