Protein Info for GFF121 in Variovorax sp. SCN45

Annotation: Uncharacterized MFS-type transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 420 transmembrane" amino acids 36 to 58 (23 residues), see Phobius details amino acids 70 to 88 (19 residues), see Phobius details amino acids 97 to 117 (21 residues), see Phobius details amino acids 124 to 144 (21 residues), see Phobius details amino acids 155 to 176 (22 residues), see Phobius details amino acids 183 to 200 (18 residues), see Phobius details amino acids 238 to 258 (21 residues), see Phobius details amino acids 274 to 292 (19 residues), see Phobius details amino acids 304 to 321 (18 residues), see Phobius details amino acids 327 to 348 (22 residues), see Phobius details amino acids 365 to 386 (22 residues), see Phobius details amino acids 391 to 411 (21 residues), see Phobius details PF00083: Sugar_tr" amino acids 36 to 204 (169 residues), 62.3 bits, see alignment E=4.1e-21 amino acids 233 to 420 (188 residues), 36.9 bits, see alignment E=2.1e-13 PF07690: MFS_1" amino acids 37 to 375 (339 residues), 165.1 bits, see alignment E=2.2e-52 amino acids 249 to 413 (165 residues), 62.9 bits, see alignment E=2.6e-21

Best Hits

Swiss-Prot: 75% identical to Y1104_HAEIN: Putative metabolite transport protein HI_1104 (HI_1104) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: None (inferred from 83% identity to dac:Daci_1524)

Predicted SEED Role

"Major facilitator superfamily (MFS) transport protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (420 amino acids)

>GFF121 Uncharacterized MFS-type transporter (Variovorax sp. SCN45)
VEARVNNAAPIAGNAATADGKDKVTGYSWKALAGSAVGYAMDGFDLLILGFMLTAISADL
HLTPGQAGSLVTWTLVGAVAGGIVFGSLSDYYGRIRVLTWTIVMFAVFTGLCAFAQGYWD
LLAYRTLAGIGLGGEFGIGMALAAEAWPAKHRARVSSYVALGWQTGVLGAALLTPLLLPH
IGWRGMFLIGVIPAVVAWVIRNKLHEPEVFVRRPAAKGSKLKAFKLLVKDGRTARTSLGL
VTLCGVQNFGYYGIMIWMPSFLANKLGFNLTKSALWTSVTILGMMLGIFVFGQLADRIGR
KPSFLLFQAGAVAMVLTYSQLSDPVSMLWAGAVMGMFVNGMLGGYGALMSEAYPTEARAT
AQNVLFNIGRGIGGFGPVVVGALATAYSFQVAIALLAAIYVLDMLATLFLIPELKGKELE