Protein Info for GFF1209 in Sphingobium sp. HT1-2

Annotation: Histidine utilization repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 236 TIGR02018: histidine utilization repressor" amino acids 4 to 233 (230 residues), 261.5 bits, see alignment E=3e-82 PF00392: GntR" amino acids 7 to 68 (62 residues), 68.2 bits, see alignment E=3.9e-23 PF07702: UTRA" amino acids 90 to 226 (137 residues), 104.8 bits, see alignment E=3.5e-34

Best Hits

KEGG orthology group: K05836, GntR family transcriptional regulator, histidine utilization repressor (inferred from 57% identity to ccs:CCNA_01013)

Predicted SEED Role

"Histidine utilization repressor" in subsystem Histidine Degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (236 amino acids)

>GFF1209 Histidine utilization repressor (Sphingobium sp. HT1-2)
VKQPLHEKIRADFEARILAGTLAPGDRLPTEQELMQAHGCSRMTVNKALSALQSAGLIER
RKKAGSFVARPRVHSMVLDIPDLAVQIGERGQRHSYRLTRRQVRGPIAGRDEEAALANGA
QLLELDGIHCADDRPLAVEHRLIATRAVPAIVDGDFDSISPGTWLLQHVPWTEAENRISA
VGATREEAALLGIAPGAPCLCVERHTWRGGDPITYVRQVFLADAYDMVARFGPAGG