Protein Info for GFF1167 in Variovorax sp. SCN45

Annotation: Predicted Lactate-responsive regulator, IclR family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 273 PF09339: HTH_IclR" amino acids 17 to 65 (49 residues), 50.5 bits, see alignment 1.4e-17 PF01614: IclR" amino acids 132 to 251 (120 residues), 104.6 bits, see alignment E=3.6e-34

Best Hits

Swiss-Prot: 30% identical to KIPR_BACSU: HTH-type transcriptional regulator KipR (kipR) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 96% identity to vap:Vapar_2376)

Predicted SEED Role

"Predicted Lactate-responsive regulator, IclR family" in subsystem Lactate utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (273 amino acids)

>GFF1167 Predicted Lactate-responsive regulator, IclR family (Variovorax sp. SCN45)
MRKNQSDIPAVPVIQVIERMFALIDVLASREEAISLKEISEKTGLHPSTTHRILNDLAVG
RFVDRPEAGSYRLGMRLLELGNLVKGRLNVRDAALGPMRELHKLTQQPVNLSMRQGDEIV
YIERSYSERSGMQVVRAIGGRAALHLTSTGKLFLAADDPQRVRSYATRTGLAGHTRNSIT
QLPALERELSKARQYGIARDNEELELGVRCMAAGIYDDQGKLVAGLSISAPADRLDEGWL
PKLQATANEISGALGFKDGVAATPANGAPSVGA