Protein Info for GFF1125 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Riboflavin kinase (EC 2.7.1.26) / FMN adenylyltransferase (EC 2.7.7.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF06574: FAD_syn
  • amino acids 1 to 150 (150 residues), 188.8 bits, E=8.7e-60
• TIGR00083: riboflavin biosynthesis protein RibF
  • amino acids 1 to 289 (289 residues), 392.2 bits, E=7.6e-122
• PF01467: CTP_transf_like
  • amino acids 2 to 153 (152 residues), 24.7 bits, E=3.6e-09
• PF01687: Flavokinase
  • amino acids 167 to 289 (123 residues), 145.2 bits, E=1.8e-46

Best Hits

Swiss-Prot: 90% identical to RIBF_SHIFL: Bifunctional riboflavin kinase/FMN adenylyltransferase (ribF) from Shigella flexneri

KEGG orthology group: K11753, riboflavin kinase / FMN adenylyltransferase [EC: 2.7.1.26 2.7.7.2] (inferred from 99% identity to ses:SARI_02949)

MetaCyc: 90% identical to bifunctional riboflavin kinase / FMN adenylyltransferase (Escherichia coli K-12 substr. MG1655)
FAD synthetase. [EC: 2.7.7.2]; Riboflavin kinase. [EC: 2.7.7.2, 2.7.1.26]

Predicted SEED Role

"Riboflavin kinase (EC 2.7.1.26) / FMN adenylyltransferase (EC 2.7.7.2)" in subsystem Riboflavin, FMN and FAD metabolism (EC 2.7.1.26, EC 2.7.7.2)

MetaCyc Pathways

• adenosylcobalamin biosynthesis II (aerobic) (29/33 steps found)
• flavin biosynthesis I (bacteria and plants) (9/9 steps found)
• flavin biosynthesis III (fungi) (8/9 steps found)
• flavin salvage (2/2 steps found)
• 5,6-dimethylbenzimidazole biosynthesis I (aerobic) (2/3 steps found)
• flavin biosynthesis II (archaea) (6/10 steps found)
• roseoflavin biosynthesis (1/7 steps found)

KEGG Metabolic Maps

• Riboflavin metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.26 or 2.7.7.2

Protein Sequence (295 amino acids)

>GFF1125 Riboflavin kinase (EC 2.7.1.26) / FMN adenylyltransferase (EC 2.7.7.2) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
VLTIGNFDGVHRGHRALLQGLQEEGRRRGLPVVVMIFEPQPLELFATDKAPARLTRLREK
LHYLAQCGVDYVLCVKFDRRFAALTAQTFISELLVERLGVQFLAVGDDFRFGASRAGDFL
LLQKAGAEYGFAVSSTQTFCEGGVRISSTAVRQALAEDNLALAESLLGHPFTISGRVVHG
DELGRTIGFPTANLPLRRQVSPVKGVYAVEVTGLGDKPLPGVANIGTRPTVAGVRQQLEV
HLLDVVMDLYGRHIDVILRKKIRNEQRFASLDELKAQIARDELTARKFFGLAGQV