Protein Info for GFF1122 in Variovorax sp. SCN45

Annotation: Molybdenum cofactor guanylyltransferase (EC 2.7.7.77)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 219 TIGR02665: molybdenum cofactor guanylyltransferase" amino acids 17 to 213 (197 residues), 220.4 bits, see alignment E=9.7e-70 PF12804: NTP_transf_3" amino acids 19 to 182 (164 residues), 126.2 bits, see alignment E=7e-41

Best Hits

Swiss-Prot: 71% identical to MOBA_ACISJ: Molybdenum cofactor guanylyltransferase (mobA) from Acidovorax sp. (strain JS42)

KEGG orthology group: K03752, molybdopterin-guanine dinucleotide biosynthesis protein A (inferred from 77% identity to vpe:Varpa_2518)

Predicted SEED Role

"Molybdopterin-guanine dinucleotide biosynthesis protein MobA" in subsystem Molybdenum cofactor biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (219 amino acids)

>GFF1122 Molybdenum cofactor guanylyltransferase (EC 2.7.7.77) (Variovorax sp. SCN45)
MTQAPAMPAHAIAPADITGLLLAGGRGSRMGGVDKGLQPFNGEPLALHAIRRLRPQVGAL
MLNANRNLKDYEAFGARVHADILADYPGPLAGFLTGLVHCRTPWLLTVPCDTPLFPPDLA
ARLAEAAATGDAEIAMAVAPEASETEGAAPVLRPQPVFCLLRADLLDSLRRYTEAGGRKV
QAWAAQHRTVRVPFDRPGDAPDAFFNANTLAELHALENR