Protein Info for GFF1108 in Variovorax sp. SCN45

Annotation: DNA polymerase III subunits gamma and tau (EC 2.7.7.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 623 TIGR02397: DNA polymerase III, subunit gamma and tau" amino acids 3 to 364 (362 residues), 398.1 bits, see alignment E=1.9e-123 PF13177: DNA_pol3_delta2" amino acids 21 to 183 (163 residues), 138.5 bits, see alignment E=6.3e-44 PF00004: AAA" amino acids 42 to 176 (135 residues), 36.1 bits, see alignment E=2.5e-12 PF22608: DNAX_ATPase_lid" amino acids 189 to 235 (47 residues), 84.4 bits, see alignment 1.1e-27 PF12169: DNA_pol3_gamma3" amino acids 240 to 369 (130 residues), 70.9 bits, see alignment E=2.9e-23 PF12170: DNA_pol3_tau_5" amino acids 494 to 615 (122 residues), 53.1 bits, see alignment E=1.2e-17

Best Hits

KEGG orthology group: K02343, DNA polymerase III subunit gamma/tau [EC: 2.7.7.7] (inferred from 88% identity to vpe:Varpa_2505)

Predicted SEED Role

"DNA polymerase III subunits gamma and tau (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (623 amino acids)

>GFF1108 DNA polymerase III subunits gamma and tau (EC 2.7.7.7) (Variovorax sp. SCN45)
MSYLVLARKFRPKTFGEMVGQGHVVQALENALTTQRLHHAYLFTGTRGVGKTTVSRILAK
SLNCQGPDGQGGITATPCGVCQACRDIDSGRFVDYTELDAASNRGVDEVQSLLEQAVYKP
VQGRFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLATTDPQKVPVTVLSRCLQFNL
RPMAPETVLEHLTGVLQTENVPAEPQALRLLARAARGSMRDALSLTDQAIAFGNGELVET
GVRQMLGSVDRGHVFRLIEALAQGDGKTVVETSEALRVDGMSAASTLEEMTAVLQAMAVL
QAVPSRAESADAATDPDAADTARLAALMPADETQLLYSLCLHGRGELGLAPDEYAALTMV
LLRLLAFKPSNAAASTASTEKKTLNEAAAAAPQAPARAPAPVPAPAPVVRPPAEQPAAAA
PAPAPISPAPTSPPAPAGQRLAVVDEPRRQPEQRPEPPDAPAKVVGVPIRVQPPPSARDI
PPAEGSQRVPYTPIPQSEDGDFWHATVTQLVASEAINALTRELALQSQLVGRDTDQWMLR
IERETLNQPSSREKLTAALNGLGHDIKLTIEIGGVVDSPARRNRQAADERQRVAEDAIHN
DPEVQALMRDFDAKIVPGTLKPA