Protein Info for GFF1098 in Methylophilus sp. DMC18

Annotation: Low affinity potassium transport system protein kup

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 626 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 51 to 72 (22 residues), see Phobius details amino acids 105 to 128 (24 residues), see Phobius details amino acids 142 to 161 (20 residues), see Phobius details amino acids 172 to 192 (21 residues), see Phobius details amino acids 216 to 237 (22 residues), see Phobius details amino acids 249 to 269 (21 residues), see Phobius details amino acids 289 to 313 (25 residues), see Phobius details amino acids 343 to 363 (21 residues), see Phobius details amino acids 369 to 390 (22 residues), see Phobius details amino acids 397 to 417 (21 residues), see Phobius details amino acids 426 to 444 (19 residues), see Phobius details PF02705: K_trans" amino acids 14 to 459 (446 residues), 600 bits, see alignment E=2.5e-184 PF22776: K_trans_C" amino acids 479 to 626 (148 residues), 155.8 bits, see alignment E=7.5e-50

Best Hits

Swiss-Prot: 60% identical to KUP1_POLSJ: Probable potassium transport system protein kup 1 (kup1) from Polaromonas sp. (strain JS666 / ATCC BAA-500)

KEGG orthology group: K03549, KUP system potassium uptake protein (inferred from 63% identity to meh:M301_0880)

Predicted SEED Role

"Kup system potassium uptake protein" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (626 amino acids)

>GFF1098 Low affinity potassium transport system protein kup (Methylophilus sp. DMC18)
METFSTKKSSLAALALGAIGVVYGDIGTSPLYTVQVIFSESTGVPLNQPNILGAISSIFW
LLMFVVTFKYVLLVLRAHNKGEGGVMALLSLAVSSLRPQDKRSTVLLLLGVLGAALFYGD
SVLTPAISVLSAVEGLQVASPTLAAQVLPISIGILIGLFWVQRHGTHAVGRFFGPVVISW
FLALACIGVWQISQAPEVLQAIHPQYAWQFLQSRGAGVFIAIGAILLAVTGAEALYADMG
HFGRPAIQLAWLGLVFPCLILNYLGQGALLLHHPEAVNNPFYLSFPEPLLIPAVILATLA
TIIASQAVISGAFSMTRQAIQLGFLPRMRIIHTSASESGQIYMPSVNWALLIAVIIVCLA
FQSSSALASAYGIAVTGTMLITTILMFIVMCKRWQFPLWLAGLLTAVLASVDGILLSSAS
MKFMQGGWFPVALSVVLILFMTTWKKGRFSLLNGIAQSDPKLLPFIESLAHCTLPRVQRT
AVYMVSNLETVPQALLHNLKHNQVLHQHNLFVNVTFEEVPFMSAEERVRVTRLAEGFWQI
QLRYGFMQHPDIPQALRSVALDGKTLDPFTNSYFLSREIIVPDVGGAMPRWRDQLFSVMS
RNASSAVEFFNIPANSVIELGSRVQL