Protein Info for GFF108 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), prokaryotic class 1A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03331: S-adenosylmethionine decarboxylase proenzyme
  • amino acids 3 to 261 (259 residues), 492.1 bits, E=1.6e-152
• PF02675: AdoMet_dc
  • amino acids 40 to 169 (130 residues), 50.2 bits, E=1.5e-17

Best Hits

Swiss-Prot: 100% identical to SPED_SALNS: S-adenosylmethionine decarboxylase proenzyme (speD) from Salmonella newport (strain SL254)

KEGG orthology group: K01611, S-adenosylmethionine decarboxylase [EC: 4.1.1.50] (inferred from 98% identity to ses:SARI_02829)

MetaCyc: 96% identical to S-adenosylmethionine decarboxylase proenzyme (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), prokaryotic class 1A" in subsystem Polyamine Metabolism (EC 4.1.1.50)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (16/17 steps found)
• superpathway of polyamine biosynthesis I (7/8 steps found)
• aminopropylcadaverine biosynthesis (3/3 steps found)
• spermidine biosynthesis I (2/2 steps found)
• spermine biosynthesis (1/2 steps found)
• spermidine biosynthesis III (2/4 steps found)
• superpathway of polyamine biosynthesis II (4/8 steps found)
• L-methionine salvage cycle III (5/11 steps found)
• L-methionine salvage cycle I (bacteria and plants) (5/12 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Methionine metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.50

Protein Sequence (264 amino acids)

>GFF108 S-adenosylmethionine decarboxylase proenzyme (EC 4.1.1.50), prokaryotic class 1A (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
LKKLKLHGFNNLTKSLSFCIYDICYAKTAEERDGYIAYIDELYNANRLTEILSETCSIIG
ANILNIARQDYEPQGASVTILVSEEPIDPKLIDQTEHPGPLPETVVAHLDKSHICVHTYP
ESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDVNGMKHF
IDHEINSIQNFMSEDMKSLYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTETE
RQEITAALWKEMREIYYGRNISAV