Protein Info for GFF1078 in Xanthobacter sp. DMC5

Annotation: Adenylosuccinate lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00928: adenylosuccinate lyase
  • amino acids 1 to 432 (432 residues), 497.9 bits, E=1.2e-153
• PF00206: Lyase_1
  • amino acids 7 to 287 (281 residues), 171.8 bits, E=2.5e-54
• PF10397: ADSL_C
  • amino acids 353 to 431 (79 residues), 85.1 bits, E=3.4e-28

Best Hits

Swiss-Prot: 52% identical to PUR8_SYNY3: Adenylosuccinate lyase (purB) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K01756, adenylosuccinate lyase [EC: 4.3.2.2] (inferred from 95% identity to xau:Xaut_3849)

MetaCyc: 37% identical to adenylosuccinate lyase (Methanocaldococcus jannaschii)
Adenylosuccinate lyase. [EC: 4.3.2.2]; 4.3.2.2 [EC: 4.3.2.2]; 4.3.2.- [EC: 4.3.2.2]

Predicted SEED Role

"Adenylosuccinate lyase (EC 4.3.2.2)" in subsystem De Novo Purine Biosynthesis or Purine conversions (EC 4.3.2.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• inosine-5'-phosphate biosynthesis I (6/6 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
• superpathway of purine nucleotide salvage (11/14 steps found)
• adenosine ribonucleotides de novo biosynthesis (3/3 steps found)
• inosine-5'-phosphate biosynthesis III (5/6 steps found)
• dZTP biosynthesis (3/5 steps found)
• tetrahydromethanopterin biosynthesis (3/14 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Biosynthesis of alkaloids derived from histidine and purine
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.3.2.2

Protein Sequence (435 amino acids)

>GFF1078 Adenylosuccinate lyase (Xanthobacter sp. DMC5)
MIPRYSRPEMASIWSPEARFRIWFEIEAHAADAMAELGIVPKEAAAKIWELGGKAEFDVE
RIDAIEREVKHDVIAFLTHLAEFVGPEARFVHQGMTSSDVLDTCLAVQLARAADLLIADV
DKLLAVLERRAFEFKLTPTVGRSHGIHAEPTTFGVKLAIAAAEFQRSRARLVAAREEIAT
CAISGAVGTFAHIDPAVEAHVAEKMGLKVETVSTQVIPRDRHAMFFAVLGVVASSVERLA
TEVRHLQRTEVLEAEEYFSPEQKGSSAMPHKRNPVLTENLTGLARMVRAYVTPALENVAL
WHERDISHSSVERMIGPDSTVTLDFALARLTGVMDKLVVHTDNMQKNMDKLGGLIHSQRV
LLALTQKGASREDSYRLVQRNAMRVWRGEGDFRTFLLNDADVRKYLSEEDINEKFDLGYH
FKNVDNIFKRVFGRA