Protein Info for GFF1063 in Methylophilus sp. DMC18

Annotation: dCTP deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF22769: DCD
  • amino acids 3 to 161 (159 residues), 125.9 bits, E=7.7e-41
• TIGR02274: deoxycytidine triphosphate deaminase
  • amino acids 4 to 189 (186 residues), 159.8 bits, E=2.8e-51

Best Hits

Swiss-Prot: 87% identical to DCD_DECAR: dCTP deaminase (dcd) from Dechloromonas aromatica (strain RCB)

KEGG orthology group: K01494, dCTP deaminase [EC: 3.5.4.13] (inferred from 95% identity to mei:Msip34_1092)

MetaCyc: 66% identical to dCTP deaminase (Rickettsia prowazekii Madrid E)
dCTP deaminase. [EC: 3.5.4.13]

Predicted SEED Role

"Deoxycytidine triphosphate deaminase (EC 3.5.4.13)" (EC 3.5.4.13)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (12/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (5/7 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.4.13

Protein Sequence (189 amino acids)

>GFF1063 dCTP deaminase (Methylophilus sp. DMC18)
MSIKSDKWIRRMAEQHGMIEPFEPTLVREVNGQKIVSYGTSSYGYDIRCADEFRVFTNIN
STIVDPKAFDPQSFVEVSGKGYCVIPPNSFALARTVEYFRIPRSVLTICLGKSTYARCGI
IVNVTPFEPEWEGYVTLEFSNTTPLPAKIYAGEGCAQVLFLESDEVCETSYKDRGGKYQG
QIGVTLPKI