Protein Info for GFF1062 in Variovorax sp. SCN45

Annotation: Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 258 PF00596: Aldolase_II" amino acids 21 to 200 (180 residues), 172.1 bits, see alignment E=5.9e-55

Best Hits

Swiss-Prot: 34% identical to Y493_RICPR: Putative aldolase class 2 protein RP493 (RP493) from Rickettsia prowazekii (strain Madrid E)

KEGG orthology group: None (inferred from 68% identity to pao:Pat9b_1815)

Predicted SEED Role

"Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (258 amino acids)

>GFF1062 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases (Variovorax sp. SCN45)
MNVAKNNPAAYPQTEAELRVQLAACYRLVAHFGMDDLIYNHISARVPGPEHHFLINPYGL
LFSEVTASSLVKIDLDGNKVDATDAEVNQAGFVIHSAIHAGRPDALCVLHTHSEAGTAIA
AMPNGLAPLSQFAMRYQGHTAFHDYEGVALETGERERLVRDLGPHHTLVLRNHGILTVGR
TIPEAFILMYYFEKAAKVQLLAQGGVAPGESLVYPQPEASELAARQFTEFAGDILPPGTR
EWPAFLRMLERTQPDYRL