Protein Info for GFF1055 in Variovorax sp. SCN45

Annotation: Fumarylacetoacetate hydrolase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 286 PF01557: FAA_hydrolase" amino acids 76 to 280 (205 residues), 225.1 bits, see alignment E=4.5e-71

Best Hits

Swiss-Prot: 41% identical to FAHD2_XENLA: Fumarylacetoacetate hydrolase domain-containing protein 2 (fahd2) from Xenopus laevis

KEGG orthology group: None (inferred from 62% identity to axy:AXYL_03120)

Predicted SEED Role

"Fumarylacetoacetate hydrolase family protein" in subsystem Gentisare degradation or Salicylate and gentisate catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (286 amino acids)

>GFF1055 Fumarylacetoacetate hydrolase family protein (Variovorax sp. SCN45)
MRLLAFQHNGKPALGLRLDSEVVNLTAEGLPATLDELLRGGPDALAAAKKAGQAARARLP
LSGIDWLPPVQSPSKAIAVGLNYIDHAAESKFEPPSYPVLFHRFPSSWVGHNQPIVRPHV
STQFDYEGELLVVIGKAGRYISKGEALNHVAGYSVFNDGSIRDYQFKSAQWMMGKNFDRS
GSFGPEFVTADELPAGAAGLRLQTRLNGTVLQDANTRDMIFDVATLVSVCSEPFALQPGD
IIIAGTPSGVGLARNPQVFMKAGDVCEVEIEGVGLLSNPVADEPRG