Protein Info for Echvi_4683 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Methylmalonyl-CoA mutase, N-terminal domain/subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01642: MM_CoA_mutase
  • amino acids 24 to 518 (495 residues), 786.9 bits, E=7.3e-241
• TIGR00641: methylmalonyl-CoA mutase N-terminal domain
  • amino acids 24 to 524 (501 residues), 845.5 bits, E=1.2e-258
• TIGR00640: methylmalonyl-CoA mutase C-terminal domain
  • amino acids 556 to 680 (125 residues), 199.5 bits, E=1.9e-63
• PF02310: B12-binding
  • amino acids 559 to 671 (113 residues), 64.8 bits, E=6.9e-22

Best Hits

Swiss-Prot: 66% identical to MUTB_PORGI: Methylmalonyl-CoA mutase large subunit (mutB) from Porphyromonas gingivalis (strain ATCC BAA-308 / W83)

KEGG orthology group: K01847, methylmalonyl-CoA mutase [EC: 5.4.99.2] (inferred from 72% identity to mtt:Ftrac_3799)

MetaCyc: 70% identical to methylmalonyl-CoA mutase large subunit (Chloroflexus aurantiacus)
Methylmalonyl-CoA mutase. [EC: 5.4.99.2]

Predicted SEED Role

"Methylmalonyl-CoA mutase (EC 5.4.99.2)" in subsystem Propionyl-CoA to Succinyl-CoA Module or Serine-glyoxylate cycle (EC 5.4.99.2)

MetaCyc Pathways

• propanoyl CoA degradation I (3/3 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• pyruvate fermentation to propanoate I (4/7 steps found)
• conversion of succinate to propanoate (1/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (6/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (10/17 steps found)
• 3-hydroxypropanoate cycle (7/13 steps found)
• superpathway of L-methionine salvage and degradation (9/16 steps found)
• methylaspartate cycle (11/19 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (10/18 steps found)
• L-glutamate degradation VIII (to propanoate) (4/11 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (5/13 steps found)
• superpathway of the 3-hydroxypropanoate cycle (7/18 steps found)
• crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) (3/14 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 5.4.99.2

Use Curated BLAST to search for 5.4.99.2

Sequence Analysis Tools

See L0G7L4 at UniProt or InterPro

Protein Sequence (685 amino acids)

>Echvi_4683 Methylmalonyl-CoA mutase, N-terminal domain/subunit (Echinicola vietnamensis KMM 6221, DSM 17526)
MRPDLTKLSQAEPFMEAADRPRPDHVRYAAGIAPFLRGPYSTMYLTRPWTLRQYAGFSTA
EASNAFYKKNLEAGQKGLSVAFDLATHRGYDSDHPRVQGDVGKAGVAIDSVLGMKLLFDG
IPLDKMSVSMTMNGAVIPVMAFYIVAAEEQGVPLDQLKGTIQNDILKEFMVRNTYIYPPE
PSLRIIADIFAFTAKNMPAFNSISISGYHMLEAGATPELELAYTLADGLEYVRTGLKAGL
AIDDFAPRLSFFWGVGMDHFTEIAKLRAGRLLWAKLMKEFRPTHPKSLKLRAHCQTSGWS
LTEQDAFNNVARTTIEALAAVMGHTQSLHTNAFDEAFALPTDFSASIARNTQVILREEYG
LRKVVDPWGGSVLLEELTEDLVKKAWAHLQEVEKMGGMAKAIEAGLPKQMIEEAAARRQA
KVDQGKEIVVGVNRFLVDEEEDFDILEVDNEAVLKQQQARLSQLKNDRDAAAVARSLEAI
TQAAKSGEGNLLELSVEAARERATLGEISMAMEKVYGRHRAKNQVVSGVYSSEAGNDELF
KEALTLTARFEKLEGRRPRILIAKMGQDGHDRGAKVIASGMADMGFDVDIGPLFQTPEEV
AKQAVENDVHLVGASSLAGGHKVLIPQLIIALEEMGRPDILVVAGGVIPPHDYEFLKEKG
VLEVFGPGTVLTKAAIRIMSVLIEE