Protein Info for Echvi_4623 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: Dihydroorotase and related cyclic amidohydrolases
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.
Best Hits
KEGG orthology group: K01465, dihydroorotase [EC: 3.5.2.3] (inferred from 39% identity to chu:CHU_1793)Predicted SEED Role
"Dihydroorotase (EC 3.5.2.3)" in subsystem De Novo Pyrimidine Synthesis (EC 3.5.2.3)
MetaCyc Pathways
- superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
- superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
- UMP biosynthesis II (6/6 steps found)
- superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
- UMP biosynthesis I (5/6 steps found)
- UMP biosynthesis III (5/6 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 3.5.2.3
Use Curated BLAST to search for 3.5.2.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0G7G5 at UniProt or InterPro
Protein Sequence (414 amino acids)
>Echvi_4623 Dihydroorotase and related cyclic amidohydrolases (Echinicola vietnamensis KMM 6221, DSM 17526) MAVLLKSLKLIQKDTIGSPQNYAYDGNQVKPYEGDESEFDEIVDCAGWLGSAGWIDLRCG VGEPGHEYQETLASLDSALQSAGFTEAVLLPNTSPVIQSKNEVEFIKNKARDFFAKLHVH AAVTKDTLGEDLTEILDIHHHGVNIFGDGNVPLSNSDRMMKVLQYLQKFDGILFDQSYDP LLAIFGQMHEGYTSTSLGMKGIPSLAEEVAIQKNIEILKYTGGSIHFQTVSTRNGVAAIR KAKEEGLQVTADVSLYQLLFVDSDLENYDSHLKVMPPFRGKEDQEALLEGLKDGTIDAIV SNHQPRDYDAKHMEFDLADFGMSGLQTFLPGMVSLEAKLGWPLLIEKITTAPGRIIRSTG KEMTSLTVFDPAEEWVFNKQTNKSLSANSPFFNQTLKGKVKLVINKDKFARLDD