Protein Info for Echvi_4472 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 644 transmembrane" amino acids 29 to 50 (22 residues), see Phobius details amino acids 59 to 77 (19 residues), see Phobius details amino acids 89 to 106 (18 residues), see Phobius details amino acids 112 to 130 (19 residues), see Phobius details amino acids 260 to 282 (23 residues), see Phobius details amino acids 294 to 316 (23 residues), see Phobius details amino acids 593 to 615 (23 residues), see Phobius details amino acids 621 to 638 (18 residues), see Phobius details TIGR01512: cadmium-translocating P-type ATPase" amino acids 94 to 640 (547 residues), 511.6 bits, see alignment E=3.4e-157 TIGR01525: heavy metal translocating P-type ATPase" amino acids 95 to 638 (544 residues), 534 bits, see alignment E=8.3e-164 TIGR01494: HAD ATPase, P-type, family IC" amino acids 116 to 616 (501 residues), 239.1 bits, see alignment E=1.1e-74 PF00122: E1-E2_ATPase" amino acids 144 to 324 (181 residues), 157.3 bits, see alignment E=4.7e-50 PF00702: Hydrolase" amino acids 341 to 547 (207 residues), 90.5 bits, see alignment E=3e-29

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 80% identity to gfo:GFO_0024)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G535 at UniProt or InterPro

Protein Sequence (644 amino acids)

>Echvi_4472 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase (Echinicola vietnamensis KMM 6221, DSM 17526)
MTKKKKINLRDLNKKKVSTGNSESKMKLGTYVPAIVSFAMLIVGISLDYFNLLPFFKGWV
RPVWYGLAYAPVGFPVIKEGWESIRKGDFFTEFFLMSIATLGAFAIGEYPEGVAVMLFYA
VGELFQNAAVKRAKGNIKALLDVRPNIALVYRDNDFVEVNPETVHIGEKVQVRTGEKIPL
DGILLSEKASVNTAAITGESKPDTIYKGNKVFAGSINLEGVIELETTKEFNDSSIARILD
MVQNATARKSKTELFIRKFARVYTPIVVFLAICLTVLPYFFVDNYVFQDWLYRALIFLVI
SCPCALVISIPLGYFGGLGAASRNGILFKGASFLDAITKVNTVVMDKTGTVTKGVFKIKE
IRPVGISENEMMSYLLALEEQSTHPIARAIMEYELNGQNHTASEVSEIGGKGLKGKVNNK
TVLVGNKALMTAHGIDVPSETDTIVESIVMITIDDQFSGYVTIADQLKEDAVEAVRQMHN
AGIKKIIMLSGDKPSITEKIGNELGLEQAKGGLLPEDKLHEVEEMKKDPSASIAFVGDGI
NDAPVLAVSDVGIAMGGLGSDVAIETADVVIQTDQPSRIARAIKIGRSTRNVVWQNIALA
FGVKLIVMILGAIGLASLWEAVFADVGVAFLAILNAIRIQKMKF