Protein Info for Echvi_4468 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 833 transmembrane" amino acids 198 to 217 (20 residues), see Phobius details amino acids 223 to 241 (19 residues), see Phobius details amino acids 253 to 269 (17 residues), see Phobius details amino acids 275 to 293 (19 residues), see Phobius details amino acids 441 to 460 (20 residues), see Phobius details amino acids 472 to 496 (25 residues), see Phobius details amino acids 786 to 805 (20 residues), see Phobius details amino acids 811 to 830 (20 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 255 to 828 (574 residues), 599.6 bits, see alignment E=1.5e-183 PF00122: E1-E2_ATPase" amino acids 305 to 500 (196 residues), 190.8 bits, see alignment E=1.6e-60 TIGR01494: HAD ATPase, P-type, family IC" amino acids 386 to 804 (419 residues), 213.5 bits, see alignment E=8.6e-67 PF00702: Hydrolase" amino acids 519 to 737 (219 residues), 124.4 bits, see alignment E=7.8e-40

Best Hits

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G5S5 at UniProt or InterPro

Protein Sequence (833 amino acids)

>Echvi_4468 heavy metal translocating P-type ATPase (Echinicola vietnamensis KMM 6221, DSM 17526)
MKKLQIKIPLLLPEVPDEKDQCVAKLIERLKNKEGLEKVHIADETDNGVPQLCFHYDPEL
ISIDRIQSLAEQTGAEITRKFGHKLIEVDGIRHTRHARNIERGLRGIAGIMEASVSASGM
VRVEYDTAKTDEAEILKALRKDGLDMPDTQVSAERFLEQVKETEKGEDQKEGNKEHVHEE
GEDHDHSHGGIFGKNTELIFSIICGALLGIGFGLTYIEAVPSWVSLSLYIGAYFFGGYFT
AKEAIQTVAKGGFEIDFLMLVAAIGAAILGEWAEGALLLFLFSMGHALEHYAMNKARKSI
AALAELAPKTALLKRNGKTEEVGIEELSIGDIIVVKPNSKISADGVVISGQSSVNQAPIT
GESVPVDKEPVDNPDKDWSQEDDIKDENRAFSGTINGNNTLEIKVIKVAKDSTLSRLVKL
VNEAQTQKSPTQRLTDKFEKYFVPSVLVLVVLLNFAFLVIDESFSESFYRAMAVLVAASP
CALAIATPSAVLSGVARAAKSGVLIKGGRPLEDLGVLTALAFDKTGTLTEGKPKLTEVVA
VGDVKEDELLKIAVAVESLSDHPLAKAVVRDGKERLDGADVPDAKDLEAVLGKGIKATLG
DDKVYIGNLDLFESLDDNKPEKETEEKVKSLESDGNTTMLIRQNDHYIGIIALMDTPRKE
AKNTLEQLKKIGIKRMIMLTGDNQKVADAVAKEIGLTDAWGSLLPEEKVEAIKKLKKNES
KVAMVGDGVNDAPAMANSTVGIAMGAAGSDVALETADIALMADKLETLPFAIALSRNAKS
IIKQNLWISLGIVGILIPLTISGIATIGPAVLIHEGSTLVVVFNALRLLAYKK