Protein Info for Echvi_4443 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: type I restriction system adenine methylase (hsdM)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 527 TIGR00497: type I restriction-modification system, M subunit" amino acids 5 to 512 (508 residues), 471.4 bits, see alignment E=1.9e-145 PF12161: HsdM_N" amino acids 9 to 172 (164 residues), 66.5 bits, see alignment E=6.3e-22 PF02384: N6_Mtase" amino acids 185 to 491 (307 residues), 370.4 bits, see alignment E=1.2e-114 PF05175: MTS" amino acids 217 to 318 (102 residues), 31.9 bits, see alignment E=1.5e-11

Best Hits

KEGG orthology group: K03427, type I restriction enzyme M protein [EC: 2.1.1.72] (inferred from 68% identity to chu:CHU_3354)

Predicted SEED Role

"Type I restriction-modification system, DNA-methyltransferase subunit M (EC 2.1.1.72)" in subsystem Restriction-Modification System (EC 2.1.1.72)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.72

Use Curated BLAST to search for 2.1.1.72

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G700 at UniProt or InterPro

Protein Sequence (527 amino acids)

>Echvi_4443 type I restriction system adenine methylase (hsdM) (Echinicola vietnamensis KMM 6221, DSM 17526)
MSEDQKQKLESQLWGIANLLRGKISADDYRDYILGFIFYKYLSEKQYLYANELLKSEGIE
DYASLTESDLLDAIKEESLLKLGYFLQPQELFSALAAKGNTDYEDPDKVEGNGSNYILDD
LQAVLNHIEQSTMGTESEDDFNALFEDLDLNSTKIGRTPNARNEIIVQILNRLNQIDFKL
EYIHSDVLGDAYEYLIAKFAAGAGKSAGEFYTPQQVSKILAKIVTTGKSKLKSVYDPTCG
SGSLLLRVAKEATVSEYYGQELNRTTYNLARMNMILHDVHFSDFDIRHEDTLENPQHKDE
RFEAIVANPPFSAHWKSDANPLNATDERFSQYGKLAPKTKADYAFVQHMLYHLADNGIMA
CVLPHGVLFRGASEGIIRQYLIKELNYLDAVIGLPANIFYGTSIPTCILVLSKCRKSDDN
IVFIDASGEDHYVKEKNQNALRDQDVELIVDTYQNRKSIDKFSYVANLAEIAENDYNLNI
PRYVDTFEEEEPVDIDAVMKEIKSLEAKRAELDQEIAGYFKELGLNF