Protein Info for Echvi_4424 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Cation/multidrug efflux pump

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1133 transmembrane" amino acids 21 to 42 (22 residues), see Phobius details amino acids 346 to 364 (19 residues), see Phobius details amino acids 371 to 392 (22 residues), see Phobius details amino acids 398 to 422 (25 residues), see Phobius details amino acids 442 to 462 (21 residues), see Phobius details amino acids 474 to 496 (23 residues), see Phobius details amino acids 516 to 533 (18 residues), see Phobius details amino acids 539 to 557 (19 residues), see Phobius details amino acids 588 to 607 (20 residues), see Phobius details amino acids 934 to 954 (21 residues), see Phobius details amino acids 961 to 980 (20 residues), see Phobius details amino acids 986 to 1011 (26 residues), see Phobius details amino acids 1051 to 1076 (26 residues), see Phobius details amino acids 1097 to 1123 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 17 to 1123 (1107 residues), 644.4 bits, see alignment E=3.1e-197 PF03176: MMPL" amino acids 291 to 463 (173 residues), 23.9 bits, see alignment E=2e-09

Best Hits

KEGG orthology group: None (inferred from 58% identity to mtt:Ftrac_0544)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G5N7 at UniProt or InterPro

Protein Sequence (1133 amino acids)

>Echvi_4424 Cation/multidrug efflux pump (Echinicola vietnamensis KMM 6221, DSM 17526)
MAEKQQDKNVTREFGLSSLAVNNKTSVIILSLIITFMGLYAYRTMPKESFPEIVIPTVYV
GTSYPGNSPVDMENLITRPIEKELKSLKDVKTIESTSIQDYSTIIIEFNPGVDISRALQD
TKDAVDKSKSELPTDLDQDPNIFELDFSEMPIMFVNLSGNYSQEELKEFGEYLEDEIEAL
PEISSADLTGTIEREIQVNADLFKMEAMEVSFGDIADAISSENVTISGGNILSGDFRRAL
RITGEFEDPEELNEIIVKSEGGNIIYLKDVAEVKDTYKERESYARASKLPVVTVNVIKRG
GENLLAASDKIKEILDEAEANHFPSDLKVSITNDQSKVTRSMVANLENSIISGIILVIIV
LMFFMGFRNALFVGIAIPLSMFISFMILNAFGVTLNMMVLFSMILALGMLVDNGIVVVEN
VYRLMQEGKTPIRAAKEGVGEVAWPIITSTATTVAAFIPLAFWQDIMGEFMKYLPITLII
VLSSSLFVGLVINPVVTAMFMKIQDLDKVKPKKRSFIIAGTLLTIAAICYIAQVFTMANI
ALIAAIITLINAVFMKRAIRWFQQVFLVWLEEKYEGLLSFALRGKKPYLFFFGMFGVLVF
SLVLLMVRSPKVEFFPSSDPNYVNIFIEYPIGTDIEATNEFSKKVEDEVMELIEPHRDIV
EAFIAQVGEGTSDPSEGPSMGVTPHKAMLTVSFVEYQYRNGKNTTKIMEELREAMAKYPG
VQITVDKEQNGPPVGKPINIEVSGEDYEKLVAEVEDIREFIKGANIGGIEELKMDLQTGK
PELIVNIDREKARRFGLSTSTIANELRTAIFGLEVSKYKEGEDDYPIQLRLAEKYRYNVD
ALVNKKIYFMDKFGNKRHIPITSVANFEYSSTYGSVKRKDLDKVITIYSNVNEGFNPTEI
NNRIRSRLEDYELPDGMDIKFTGEQEEQAKSMEFLMRAMMIAVAAIFLIIVAQFNSLMTP
FIIMCSVILSTIGVFIGLATFNMDFVVIMTGIGIISLAGVVVNNAIVLIDYTNLVRQRKR
SDRGLGEDEHLTYDDLVASIVEGGKTRLRPVLLTAITTILGLIPMAIGMNIDFFSLLSDF
DPQFYVGGDNADFWGPMAWTVIFGLTFATFLTLVIVPVMYLLADKINIAIRRK