Protein Info for Echvi_4408 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Mannose-1-phosphate guanylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 332 PF00483: NTP_transferase" amino acids 5 to 268 (264 residues), 150.1 bits, see alignment E=1.3e-47 PF12804: NTP_transf_3" amino acids 6 to 126 (121 residues), 32.8 bits, see alignment E=1.1e-11 PF01050: MannoseP_isomer" amino acids 291 to 328 (38 residues), 29.8 bits, see alignment 8.1e-11

Best Hits

KEGG orthology group: K00971, mannose-1-phosphate guanylyltransferase [EC: 2.7.7.22] (inferred from 60% identity to zpr:ZPR_0538)

Predicted SEED Role

"Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22)" in subsystem Alginate metabolism or Mannose Metabolism (EC 2.7.7.22)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.22

Use Curated BLAST to search for 2.7.7.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G4Y1 at UniProt or InterPro

Protein Sequence (332 amino acids)

>Echvi_4408 Mannose-1-phosphate guanylyltransferase (Echinicola vietnamensis KMM 6221, DSM 17526)
MKITNVVLSGGVGSRLWPLSRKSCPKQYLPIFEERTLFQKTVERNQPLCDQLMIVGNQAN
YELSRKDIKGLGITKYIEVIEACPRNTAAAIAFAAFRSGPEDILFVTPSDHLITTGDAYT
KSVERAIELAKEDHIVTFGLKPTRPETGFGYIEADGESVKGFREKPDLATAEQFLEQGNF
LWNSGMFCFKAQVFLSELESYEPEVFKRSQEAMEAASDGFLDKELSMKIPSISVDYAVME
RTRKIKVVPSSFGWSDMGSFESVFEYMEQHGYEPDAQGNMIIGSNVHTEFVGLENTILVQ
TKDAILVLKKESAQDVKKVFEKLEKDKPELVD