Protein Info for Echvi_4310 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: N-acetyl-beta-hexosaminidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 535 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF02838: Glyco_hydro_20b" amino acids 26 to 150 (125 residues), 74.7 bits, see alignment E=1.1e-24 PF00728: Glyco_hydro_20" amino acids 154 to 501 (348 residues), 330.9 bits, see alignment E=1.1e-102

Best Hits

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 49% identity to fbc:FB2170_13933)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G5C4 at UniProt or InterPro

Protein Sequence (535 amino acids)

>Echvi_4310 N-acetyl-beta-hexosaminidase (Echinicola vietnamensis KMM 6221, DSM 17526)
MKYTRSVCFLLGWMVAVMAHADLEAQIIPYPLSIVALEGALELNAGVPIIAGDGLGTEAG
FLSDYLKEHFQTASPIMENGSGIQLRLNGDLADSLGNEGYSMVIDQSIEIVAPTPTGIFY
GVQTLKQLLAPEFSKGVTDHVQVANTRIVDRPRFSWRAFMLDDCRNFMGMDVVKKMLDHM
AMLKMNVFHWHLTDDQAWRIEIKKYPKLTEVGGTRKDTQLARGSSDRVGEPQTGHYTQEE
IREIIRYAADRHIVIVPEIEMPGHAMAAIAAYPWIGSLGTTVEVPVTFGKMEDSFNVTDP
RVVRFLKDILDEVAALFPGDAIHIGGDEVNHNPWMDSESIRGYMRANGLSTPMDLQIHFT
NQISSYLASKGKRMMGWNDILGHDIHDERSGSTEKVEQTLEKSSIVHFWKGDLGLVESAA
RDGYEVVNSNHWDTYLDYTYQRLPLSKAYAFDPVPAGLPEAYHGKILGLGTQMWTEYTRT
EADMLRQAFPRILAYAEVGWSFPENKNYDRFLKAVKGITMQFRQNGIVFGDYLEE