Protein Info for Echvi_4177 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 327 PF00248: Aldo_ket_red" amino acids 16 to 303 (288 residues), 237.6 bits, see alignment E=8.4e-75

Best Hits

Swiss-Prot: 44% identical to AKR2_ORYSI: Probable aldo-keto reductase 2 (OsI_15387) from Oryza sativa subsp. indica

KEGG orthology group: None (inferred from 72% identity to shg:Sph21_0126)

MetaCyc: 44% identical to perakine reductase (Rauvolfia serpentina)
RXN-12673 [EC: 1.1.1.317]

Predicted SEED Role

"Aldo-keto reductase"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.317

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G696 at UniProt or InterPro

Protein Sequence (327 amino acids)

>Echvi_4177 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) (Echinicola vietnamensis KMM 6221, DSM 17526)
MEKRTLGNQGLKVSALGLGCMGLSFGYGPPTEKNAAIKLIRSAFEQGITFFDTAECYGPF
TNEELVGEAIAPFRKEVVIATKFGFKDGDSKKGLDSSPKRIREVAESSLRRLNTDHIDLF
YQHRVDPSVPMEDVAGTMSDLIKEGKIGHWGLSEAGATTIRKAHAIQPLAALQSEYSLFY
REPEKEIIPLLEEFGIGFVPFSPLGKGFLTGAISESTQFDPNDFRNTVPRFSKENRKANQ
ALVDLVKKIAVQKQATPGQIALGWLLAQKPFILPIPGTTKQHRLTENVGSTKINLSDDDL
FQVSTALKNIQLVGERYSAAAQKMIDR