Protein Info for Echvi_4125 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: copper-(or silver)-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 745 transmembrane" amino acids 102 to 121 (20 residues), see Phobius details amino acids 127 to 149 (23 residues), see Phobius details amino acids 161 to 180 (20 residues), see Phobius details amino acids 192 to 211 (20 residues), see Phobius details amino acids 345 to 366 (22 residues), see Phobius details amino acids 373 to 396 (24 residues), see Phobius details amino acids 691 to 710 (20 residues), see Phobius details amino acids 717 to 738 (22 residues), see Phobius details PF00403: HMA" amino acids 16 to 75 (60 residues), 51.4 bits, see alignment 2.3e-17 TIGR01511: copper-translocating P-type ATPase" amino acids 141 to 741 (601 residues), 609.1 bits, see alignment E=1.8e-186 TIGR01525: heavy metal translocating P-type ATPase" amino acids 159 to 740 (582 residues), 638 bits, see alignment E=3.4e-195 TIGR01494: HAD ATPase, P-type, family IC" amino acids 200 to 708 (509 residues), 301.8 bits, see alignment E=1.4e-93 PF00122: E1-E2_ATPase" amino acids 229 to 409 (181 residues), 195.4 bits, see alignment E=1.3e-61 PF00702: Hydrolase" amino acids 427 to 645 (219 residues), 122 bits, see alignment E=8.6e-39 PF08282: Hydrolase_3" amino acids 620 to 677 (58 residues), 22 bits, see alignment 2.5e-08

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 76% identity to mtt:Ftrac_2059)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G5P3 at UniProt or InterPro

Protein Sequence (745 amino acids)

>Echvi_4125 copper-(or silver)-translocating P-type ATPase (Echinicola vietnamensis KMM 6221, DSM 17526)
MDTIVAPRKTVKKESFPVTGMTCASCASSVESILSHIDGVSQASVNFASNSVLVEHDPSV
SPLDLQNALRSVGYDLIIDEENPSQAQEERQRQHYLEVRNRTIWSALLTFPVFILGMFYM
NWMPGQWISLLLTIPILFYFGKNFFINAFKQAKHGKANMDTLVALSTGIAFVFSLFNTLF
PDFWHARGIHPHVYYEAATVIITFISLGKLLEEKAKSNTSSAIKKLMGLQPKTLRAIING
EELEIPIASVQKGNTILVRPGEKIPVDGAVLSGSSYIDESMITGEPVPVAKIKGDKVFAG
TVNQKGSFQFEAEKVGGETLLSQIIKMVQEAQGSKAPVQKLVDKIAGIFVPVVMGISIFT
FIVWMTVGGDDAFTHALLTSVAVLVIACPCALGLATPTAIMVGVGKGAENNILIKDAESL
ELGHKVNAIVLDKTGTITEGKPTVTNLYWSEKAHEAYHAAVLLALETQSEHPLADAVVKK
LKEKGVQRETLKDFDSLTGKGVKASDTAGKTYYIGNGKLMQEYQINIPQHIQQKAGEWQK
EAKTVVFFSDDVEVLAVLAIADKIKATSRSAVEKLKKLGVEVYMLTGDNNQTARAVAAQV
GLTDFKGEVLPSDKADFVRELQSKGKVVAMVGDGINDSQALAQANVSIAMGHGSDIAMDV
AKMTLITSDLESIPKALKLSSKTVKGIRQNLFWAFIYNVIGIPIAAGILYPVNGFLLDPM
IAGAAMALSSVSVVANSLRLKTTKI